3-Thia-4-arylquinolin-2-one potassium channel modulators

1. A compound of formula (I)

wherein:

R and R 1 are independently hydrogen or methyl;

R 2 , R 3 , and R 4 are independently hydrogen, halogen, cyano, nitro, or trifluoromethyl, provided R 2 , R 3 , and R 4 are not all hydrogen;

R 5 is bromo, chloro, or nitro;

R 6 and R 7 are independently hydrogen, C 1-6 alkyl, C 1-6 alkenyl, C 3-7 cycloalkyl, —CH 2 C 3-7 cycloalkyl, —(CH 2 ) 1-3 OH, —(CH 2 ) 2-3 NR 8 R 9 , —(CH 2 ) 1-3 CN, or —(CH 2 ) 1-3 Ar, where Ar is selected from the group consisting of phenyl, naphthyl, furanyl, thienyl, and pyridyl, and Ar is unsubstituted or substituted with 1–2 methoxy substituents;

or NR 6 R 7 taken together form

or NR 6 R 7 taken together is selected from the group consisting of

R 8 and R 9 are independently hydrogen or C 1-6 alkyl;

R 10 is a bond, O, S, NR 11 , or CHR 12 ;

R 11 is hydrogen, C 1-6 alkyl, CHO, C(O)Me, —(CH 2 ) 2-3 OH, —CH 2 CH 2 OCH 2 CH 2 OH, —(CH 2 ) 2-3 NR 8 R 9 , —(CH 2 ) 2-3 CONR 8 R 9 , —C(O)furanyl, —CH 2 CH═CHPh, pyridinyl, pyrazinyl, or anisolyl;

R 12 is hydrogen, hydroxy, C 1-6 alkyl, —CH 2 Ph, —C(O)OR 8 , —CONR 8 R 9 , —(CH 2 ) 1-3 NR 8 R 9 , or 1-piperidinyl; and

p is 1, 2 or 3;

or a pharmaceutically acceptable salt thereof.

2. A compound of claim 1 where R is hydrogen.

3. A compound of claim 1 where R 1 is hydrogen.

4. A compound of claim 1 where R 2 is hydrogen, R 3 is trifluoromethyl, and R 4 is hydrogen.

5. A compound of claim 1 where R 5 is chloro.

6. A compound of claim 1 selected from the group consisting of

(1) 4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-4-morpholin-4-yl-butylsulfanyl)-6-trifluoromethyl-1H-quinolin-2-one;

(2) 4-(5-Chloro-2-methoxy-phenyl)-3-(2-hydroxy-3-pyrrolidin-1-yl-propylsulfanyl)-6-trifluoromethyl-1H-quinolin-2-one;

(3) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-(1-piperidinyl)butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(4) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-(4-methyl-1-piperazinyl)butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(5) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-(3-hydroxy-1-pyrrolidinyl)butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(6) 1-[4-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-3-hydroxybutyl]-(2S)-2-pyrrolidinecarboxamide;

(7) 1-[4-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-3-hydroxybutyl]-3-piperidinecarboxylic acid, ethyl ester;

(8) 4-(5-Chloro-2-hydroxyphenyl)-3-[[4-(3,6-dihydro-1(2H)-pyridinyl)-2-hydroxybutyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(9) 4-(5-Chloro-2-hydroxyphenyl)-3-[[4-[(2-furanylmethyl)methylamino]-2-hydroxybutyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(10) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-(2-methyl-1-piperidinyl)butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(11) 3-[[4-[Bis(2-hydroxyethyl)amino]-2-hydroxybutyl]thio]-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(12) 4-(5-Chloro-2-hydroxyphenyl)-3-[[4-(5-ethyl-2-methyl-1-piperidinyl)-2-hydroxybutyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(13) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-[3-(hydroxymethyl)-1-piperidinyl]butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(14) 4-(5-Chloro-2-hydroxyphenyl)-3-[[4-[[2-(diethylamino)ethyl]methylamino]-2-hydroxybutyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(15) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-[methyl(2-methylpropyl)amino]butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(16) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-[methyl(2-phenylethyl)amino]butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(17) 4-(5-Chloro-2-hydroxyphenyl)-3-[[4-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-2-hydroxybutyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(18) 4-Acetyl-alpha-[[[4-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]methyl]-1-piperazinepropanol;

(19) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-(3-methyl-1-piperidinyl)butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(20) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-(4-methyl-1-piperidinyl)butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(21) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-(4-hydroxy-1-piperidinyl)butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(22) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-(4-thiomorpholinyl)butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(23) 1-[4-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-3-hydroxybutyl]-3-piperidinecarboxamide;

(24) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-[methyl(1-methyl-3-pyrrolidinyl)amino]butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(25) 4-(5-Chloro-2-hydroxyphenyl)-3-[[4-(4-ethyl-1-piperazinyl)-2-hydroxybutyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(26) 4-(5-Chloro-2-hydroxyphenyl)-3-[[4-[[3-(dimethylamino)propyl]methylamino]-2-hydroxybutyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(27) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-4-[2-(hydroxymethyl)-1-piperidinyl]butyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(28) 3-[(4-[1,4′-Bipiperidin]-1′-yl-2-hydroxybutyl)thio]-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(29) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(1-piperidinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(30) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(3-hydroxy-1-pyrrolidinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(31) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(4-thiomorpholinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(32) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-(cyclohexylmethylamino)-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(33) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-[(cyclopropylmethyl)propylamino]-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(34) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[(2-phenylethyl)(phenylmethyl)amino]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(35) 1-[5-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-4-hydroxypentyl]-3-piperidinecarboxylic acid, ethyl ester;

(36) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(octahydro-1(2H)-quinolinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(37) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(4-methyl-1-piperazinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(38) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[4-(phenylmethyl)-1-piperidinyl]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(39) 4-[5-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-4-hydroxypentyl]-1-piperazinecarboxaldehyde;

(40) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-[(2-furanylmethyl)methylamino]-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(41) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-(dipropylamino)-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(42) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-[[2-(dimethylamino)ethyl]methylamino]-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(43) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[(2-hydroxy-2-phenylethyl)methylamino]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(44) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(2-methyl-1-piperidinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(45) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[4-(2-hydroxyethyl)-1-piperazinyl]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(46) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-(5-ethyl-2-methyl-1-piperidinyl)-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(47) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[3-(hydroxymethyl)-1-piperidinyl]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(48) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[methyl(2-methylpropyl)amino]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(49) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[methyl(2-phenylethyl)amino]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(50) 3-[[5-[Butyl(phenylmethyl)amino]-2-hydroxypentyl]thio]-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(51) 4-Acetyl-alpha-[[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]methyl]-1-piperazinebutanol;

(52) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(1-pyrrolidinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(53) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(3-methyl-1-piperidinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(54) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(4-methyl-1-piperidinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(55) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(4-hydroxy-1-piperidinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(56) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-(4-morpholinyl)pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(57) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[methyl(1-methyl-3-pyrrolidinyl)amino]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(58) 1-[5-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-4-hydroxypentyl]-4-piperidinecarboxylic acid, ethyl ester;

(59) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-[[3-(dimethylamino)propyl]methylamino]-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(60) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[2-(hydroxymethyl)-1-piperidinyl]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(61) 3-[(5-[1,4′-Bipiperidin]-1′-yl-2-hydroxypentyl)thio]-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(62) 3-[[5-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-4-hydroxypentyl]methylamino]propanenitrile;

(63) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-(3,4-dihydro-1(2H)-quinolinyl)-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(64) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-(cyclohexyl-2-propenylamino)-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(65) 3-[[5-[Bis(phenylmethyl)amino]-2-hydroxypentyl]thio]-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(66) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(67) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[methyl[2-(2-pyridinyl)ethyl]amino]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(68) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-[[2-(diethylamino)ethyl]methylamino]-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(69) 4-(5-Chloro-2-hydroxyphenyl)-3-[[5-(di-2-propenylamino)-2-hydroxypentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(70) alpha-[[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]methyl]-4-(2-furanylcarbonyl)-1-piperazinebutanol;

(71) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[4-[(2E)-3-phenyl-2-propenyl]-1-piperazinyl]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(72) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(73) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-5-[methyl[(1R)-1-(1-naphthalenyl)ethyl]amino]pentyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(74) 4-(5-Chloro-2-hydroxyphenyl)-3-[[3-(diethylamino)-2-hydroxypropyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(75) 4-(5-Chloro-2-hydroxyphenyl)-3-[[(2S)-3-(diethylamino)-2-hydroxypropyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(76) 4-(5-Chloro-2-hydroxyphenyl)-3-[[(2R)-3-(diethylamino)-2-hydroxypropyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(77) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-(1-piperidinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(78) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-(4-morpholinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(79) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(80) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-[4-(2-pyridinyl)-1-piperazinyl]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(81) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-(1-pyrrolidinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(82) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-(4-morpholinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(83) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-[4-(2-pyridinyl)-1-piperazinyl]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(84) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(85) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-(4-thiomorpholinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(86) 4-(5-Chloro-2-hydroxyphenyl)-3-[[3-[4-[2-(dimethylamino)ethyl]-1-piperazinyl]-2-hydroxypropyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(87) 4-(5-Chloro-2-hydroxyphenyl)-3-[[3-[[3-(dimethylamino)propyl]methylamino]-2-hydroxypropyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(88) 3-[[3-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-2-hydroxypropyl]methylamino]propanenitrile;

(89) 3-[[3-[[4-(5-Chloro-2-methoxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-2-hydroxypropyl]methylamino]propanenitrile;

(90) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-(4-thiomorpholinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(91) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-(3-hydroxy-1-pyrrolidinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(92) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-[4-(2-pyrimidinyl)-1-piperazinyl]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(93) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-[(2-hydroxyethyl)(1-methylethyl)amino]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(94) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-[2-(hydroxymethyl)-1-pyrrolidinyl]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(95) 1-[3-[[4-(5-Chloro-2-methoxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-2-hydroxypropyl]-2-pyrrolidinecarboxamide;

(96) 1-[3-[[4-(5-Chloro-2-methoxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-2-hydroxypropyl]-3-piperidinecarboxylic acid, ethyl ester;

(97) 4-Acetyl-alpha-[[[4-(5-Chloro-2-methoxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]methyl]-1-piperazineethanol;

(98) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(99) 4-(5-Chloro-2-methoxyphenyl)-3-[[3-[ethyl(2-hydroxyethyl)amino]-2-hydroxypropyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(100) 3-[[3-[Bis(2-hydroxyethyl)amino]-2-hydroxypropyl]thio]-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(101) 3-[[3-[Bis(2-hydroxypropyl)amino]-2-hydroxypropyl]thio]-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(102) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-(4-methyl-1-piperazinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(103) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-(1H-imidazol-1-yl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(104) 1-[3-[[4-(5-Chloro-2-methoxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-2-hydroxypropyl]-4-piperidinecarboxamide;

(105) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(106) 4-[3-[[4-(5-Chloro-2-methoxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-2-hydroxypropyl]-N,N-dimethyl-1-piperazineacetamide;

(107) 4-(5-Chloro-2-methoxyphenyl)-3-[[2-hydroxy-3-(4-methyl-1-piperidinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(108) 3-[[3-(Butylmethylamino)-2-hydroxypropyl]thio]-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(109) 3-[[3-(Butylmethylamino)-2-hydroxypropyl]thio]-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(110) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-(3-hydroxy-1-pyrrolidinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(111) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-[2-(hydroxymethyl)-1-pyrrolidinyl]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(112) 1-[3-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-2-hydroxypropyl]-3-piperidinecarboxylic acid, ethyl ester;

(113) 4-Acetyl-alpha-[[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]methyl]-1-piperazineethanol;

(114) 1-[3-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-2-hydroxypropyl]-4-piperidinecarboxamide;

(115) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(116) 4-[3-[[4-(5-Chloro-2-hydroxyphenyl)-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-quinolinyl]thio]-2-hydroxypropyl]-N,N-dimethyl-1-piperazineacetamide;

(117) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-[(2-hydroxyethyl)(1-methylethyl)amino]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(118) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-(1-piperidinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(119) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-[(2-hydroxyethyl)methylamino]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(120) 3-[[3-[Bis(2-hydroxyethyl)amino]-2-hydroxypropyl]thio]-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(121) 3-[[3-[Bis(2-hydroxypropyl)amino]-2-hydroxypropyl]thio]-4-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)-2(1H)-quinolinone;

(122) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-(4-methyl-1-piperazinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(123) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-(1H-imidazol-1-yl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(124) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-(3-thiazolidinyl)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(125) 4-(5-Chloro-2-hydroxyphenyl)-3-[[3-(3,5-dimethyl-1-piperazinyl)-2-hydroxypropyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(126) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-[(4-hydroxybutyl)methylamino]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(127) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-[methyl(phenylmethyl)amino]propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(128) 4-(5-Chloro-2-hydroxyphenyl)-3-[[3-[ethyl(phenylmethyl)amino]-2-hydroxypropyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone;

(129) 4-(5-Chloro-2-hydroxyphenyl)-3-[[2-hydroxy-3-(methylamino)propyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone; and

(130) 4-(5-Chloro-2-hydroxyphenyl)-3-[[3-(ethylamino)-2-hydroxypropyl]thio]-6-(trifluoromethyl)-2(1H)-quinolinone.

7. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.

8. A method of modulating potassium channels for the treatment of erectile dysfunction or irritable bowel syndrome, comprising administering a therapeutically effective amount of a compound of claim 1 to a patient in need thereof.