Methods of determining concentration of glucose
A region of skin, other than the fingertips, is stimulated. After stimulation, an opening is created in the skin (e.g., by lancing the skin) to cause a flow of body fluid from the region. At least a portion of this body fluid is transported to a testing device where the concentration of analyte (e.g., glucose) in the body fluid is then determined. It is found that the stimulation of the skin provides results that are generally closer to the results of measurements from the fingertips, the traditional site for obtaining body fluid for analyte testing.
1. A method of determining a concentration of glucose in blood, the method comprising:
stimulating a region of skin other than a fingertip for a period of time adequate to obtain a glucose concentration measurement that is at least 10% closer to a glucose concentration determined from blood obtained from a fingertip measurement than a determination of a glucose concentration from blood obtained from the region of skin without stimulating;
after stimulating the region of the skin, lancing the skin to cause a flow of blood from the region;
contacting a portion of an electrchemical sensor to the blood and transporting at least a portion of the blood to a sample chamber of the electrochemical sensor; and
electrochemically determining the concentration of glucose an the blood sample.
2. The method of claim 1 wherein the step of stimulating the region of skin other than a fingertip comprises stimulating a region of skin of one of an upper arm, a thigh, a calf, a hand or an abdomen.
3. The method of claim 1 wherein the step of stimulating the region of skin comprises manually rubbing the skin for a period of at least one second.
4. The method of claim 3 wherein the step of stimulating the region of skin comprises manually rubbing the skin for a period of at least 2 seconds.
5. The method of claim 1 wherein the step of transporting at least a portion of the blood to a sample chamber comprises transporting no more than about 1 microliter of blood to the sample chamber.
6. The method of claim 5 wherein the step of transporting no more than about 1 microlter of the blood comprises transporting no more than about 0.5 microliter of the blood.
7. The method of claim 6 wherein the step of transporting no more than about 0.5 microliter of the blood comprises transporting no more than about 0.25 microliter of the blood.
8. The method of claim 7 wherein the step of transporting no more than about 0.25 microliter of the blood comprises transporting no more than about 0.1 microliter of the blood.