Immunomodulatory protein and useful embodiments thereof
The invention generally features the use of Yaba monkey tumor virus nucleic acid molecules and polypeptides for the treatment or prevention of immune-related diseases.
1. A purified nucleic acid molecule derived from the Yaba Monkey Tumor Virus having at least 99% nucleic acid sequence identity to SEQ ID NO:1, wherein said nucleic acid molecule encodes a polypeptide that modulates cytokine function.
2. The nucleic acid molecule of claim 1 , wherein said nucleic acid molecule comprises the nucleic acid sequence of SEQ ID NO:1.
3. The nucleic acid molecule of claim 1 , wherein said nucleic acid molecule consists of SEQ ID NO:1.
4. A nucleic acid molecule comprising a sequence complementary to a nucleic acid sequence having at least 99% identity to SEQ ID NO:1.
5. The nucleic acid molecule of claim 1 , wherein each T is replaced with a U.
6. A vector comprising the nucleic acid molecule of claim 1 .
7. The vector of claim 6 , wherein said nucleic acid molecule is positioned for expression.
8. The vector of claim 6 , wherein said nucleic acid molecule is under the control of an inducible promoter.
9. The vector of claim 6 , wherein said vector is suitable for expression in a mammalian cell.
10. A pharmaceutical composition comprising the nucleic acid molecule of claim 1 formulated in a pharmaceutically acceptable carrier in an amount sufficient to treat an immune disorder or inflammation when administered to a cell of a subject.
11. The purified nucleic acid molecule of claim 1 , wherein said nucleic acid molecule encodes a Yaba Monkey Tumor Virus polypeptide.
12. The purified nucleic acid molecule of claim 11 , wherein said nucleic acid molecule encodes a polypeptide comprising an amino acid sequence having at least 99% amino acid sequence identity to SEQ ID NO:2.
13. The purified nucleic acid molecule of claim 12 , wherein said nucleic acid molecule encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2.
14. The purified nucleic acid molecule of claim 13 , wherein said nucleic acid molecule encodes a polypeptide consisting of the amino acid sequence of SEQ ID NO:2.
15. A vector comprising the nucleic acid molecule of claim 11 .
16. The vector of claim 15 , wherein said nucleic acid molecule is positioned for expression.
17. The vector of claim 15 , wherein said nucleic acid molecule is under the control of an inducible promoter.
18. The vector of claim 15 , wherein said vector is suitable for expression in a mammalian cell.
19. A vector comprising the nucleic acid molecule of claim 13 .