MCP-1 receptor antibodies
View Patent ↗Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in an assay to identify antagonists of MCP-1 which are therapeutically useful in the treatment of atherosclerosis and other diseases characterized by monocytic infiltrates.
1. An antibody which specifically binds MCP-1 receptor polypeptide, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO: 2.
2. A composition comprising an antibody according to claim 1 and a pharmaceutically acceptable carrier.
3. A method of making an antibody that binds MCP-1 receptor polypeptide comprising:
(a) immunizing an animal with the polypeptide comprising SEQ ID NO: 2; and
(b) isolating the antibody.
4. An antibody or fragment thereof which specifically binds MCP-1 receptor polypeptide consisting of SEQ ID NO: 2.
5. A composition comprising an antibody according to claim 4 and a pharmaceutically acceptable carrier.