Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
The present invention provides new uses of DPIV-inhibitors of the present invention, and their corresponding pharmaceutically acceptable acid addition salt forms, for treating conditions mediated by DPIV or DPIV-like enzymes, such as cancer and tumors. In a more preferred embodiment, the compounds of the present invention are useful for the treatment of metastasis and tumor colonization.
1. A method for treating breast cancer, the method comprising administering to a subject in need thereof a therapeutically effective amount of at least one inhibitor of dipeptidyl peptidase IV (DPIV), wherein said inhibitor is an amino acid linked to a thiazolidine or a pyrrolidine group by a peptide bond.
2. The method according to claim 1 , wherein treating comprises treating tumor cell metastasis.
3. The method according to claim 1 , wherein treating comorises treating tumor colonization.
4. The method according to claim 1 , wherein the at least one inhibitor is selected from the group consisting of L-threo-isoleucyl pyrrolidine, L-allo-isoleucyl thiazolidine, L-allo-isoleucyl pyrrolydine, L-glutaminyl thiazolidine, L-glutaminyl pyrrolidine, L-glutamic acid thiazolidine, L-glutamic acid pyrrolidine and salts thereof.
5. A method according to claim 1 wherein the amino acid is selected from the group consisting of leucine, valine, glutamine, glutamic acid, proline, isoleucine, asparagine and aspartic acid.