Human sperm specific lysozyme-like proteins
The present invention relates to two novel, testis-specific proteins (C19 and C23) that arc lysozyme paralogues. The proteins are believed to play a role in capacitation of sperm and the fertilization of the ovum. Therefore these compounds make ideal targets for the design of contraceptive agents. The C19 and C23 proteins can also be modified to establish lysozyme activity and the modified proteins can then be used in all applications that currently exist for lysozymes.
1. A method for inhibiting sperm binding to an oocyte in vitro, said method comprising contacting the sperm with an antibody directed against the polypeptide of SEQ ID NO: 2 prior to binding of said sperm with said oocyte, wherein said antibody inhibits sperm binding to the oocyte.
2. The method of claim 1 wherein said antibody is a polyclonal antibody or a monoclonal antibody.