Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith
Alcohol and water solvates of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt are crystalline and have the formula wherein R 1 is H or lower alkyl, and x is a number from 0 to 10, and are useful for treating dyslipidemia.
1. A compound that is 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt of formula II:
wherein R 1 is C 1 –C 4 alkyl and x is a number from 1 to 10.
2. A crystalline compound selected from the group consisting of:
6-(5 -carboxy-5 -methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt methanol solvate;
6-(5-carboxy-5 -methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt ethanol solvate;
6-(5 -carboxy-5 -methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt 1-propyl alcohol solvate;
6-(5-carboxy-5 -methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt 2-propyl alcohol solvate; and
6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt 1-butyl alcohol solvate.
3. The crystalline compound of claim 2 wherein said compound comprises 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt ethanol solvate.
4. The crystalline compound of claim 2 wherein said compound comprises 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt methanol solvate.
5. The crystalline compound of claim 2 wherein said compound comprises 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt 1 -propyl alcohol solvate.
6. The crystalline compound of claim 2 wherein said compound comprises 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt 2-propyl alcohol solvate.
7. The crystalline compound of claim 2 wherein said compound comprises 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt 1 -butyl alcohol solvate.
8. A pharmaceutical composition comprising a compound of claim 2 together with one or more pharmaceutically acceptable diluents, carriers or excipients.
9. A method of treating a vascular disease in a patient in need thereof, said method comprising administering to the patient a therapeutically effective amount of a compound of claim 2 .