Ubiquitin-specific protease occurring in the brain and DNA encoding the same
A ubiquitin-specific protease occurring in the brain and a DNA encoding it, which are useful for research on the molecular mechanism of the neuroplasticity expression and so on.
1. An isolated ubiquitin-specific protease that comprises the amino acid sequence set forth in SEQ ID NO:2.
2. The ubiquitin-specific protease according to claim 1 , which consists of the amino acid sequence of SEQ ID NO:2.
3. An isolated DNA which encodes the ubiquitin-specific protease as defined in claim 1 or 2 .
4. The DNA according to claim 3 , which has the nucleotide sequence of the nucleotide numbers 178 to 3285 in the nucleotide sequence of SEQ ID NO: 1.
5. The DNA according to claim 4 which consists of the nucleotide sequence of the nucleotide numbers 178 to 3285 in the nucleotide sequence of SEQ ID NO:1.
6. A recombinant vector comprising the DNA as defined in claim 3 .
7. An isolated host cell transformed with the DNA as defined in claim 3 .
8. A method for producing a ubiquitin-specific protease, which comprises culturing the host cell as defined in claim 7 and isolating a ubiquitin-specific protease expressed by the host cell from the host cell culture.