Angiogenesis inhibitors
A method for treating an angiogenesis-related disorder. The method includes administrating to a subject in need thereof an effective amount of a compound of the formula: Each of Ar 1 , Ar 2 , and Ar 3 , independently, is phenyl, thienyl, furyl, pyrrolyl, pyridinyl, or pyrimidinyl; each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is R, nitro, halogen, C(O)OR, C(O)SR, C(O)NRR′, (CH 2 ) m OR, (CH 2 ) m SR, (CH 2 ) m NRR′, (CH 2 ) m CN, (CH 2 ) m C(O)OR, (CH 2 ) m CHO, (CH 2 ) m CH═NOR, or R 1 and R 2 together, R 3 and R 4 together, or R 5 and R 6 together are O(CH 2 ) m O, in which each of R and R′, independently, is H or C 1 ˜C 6 alkyl; and m is 0, 1, 2, 3, 4, 5, or 6, and n is 0, 1, 2, or 3.
1. A method for inhibiting endothelial cell proliferation, comprising administering to a subject in need thereof an effective amount of a compound of the formula:
Wherein
each of Ar 1 , and Ar 3 is phenyl;
Ar 2 is furyl or phenyl;
one of R 1 , and R 2 is H, and the other is C 1 –C 6 alkyl or halogen;
one of R 3 , and R 4 is H, and the other is CH 2 OH;
each of R 5 , and R 6 is H;
n is 1; and
said endothelial cell proliferation is responsible for treating an angiogenesis-related disorder.
2. The method of claim 1 , wherein Ar 2 is 5′-furyl.
3. The method of claim 2 , wherein R 3 is substituted at position 2 of furyl.
4. The method of claim 3 , wherein R 3 is CH 2 OH and R 4 is H.
5. The method of claim 4 , wherein R 1 and R 2 are substituted at positions 4 and 5 of phenyl.
6. The method of claim 5 , wherein R 1 is H, and R 2 is CH 3 .
7. The method of claim 6 , wherein R 1 is H, and R 2 is F.