Peptides that home to tumor lymphatic vasculature and methods of using same
The present invention provides a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature. The invention also provides a method of directing a moiety to tumor lymphatic vasculature in a subject by administering to the subject a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature.
1. An isolated peptide, comprising the amino acid sequence GNKRTRG (SEQ ID NO: 2), wherein said peptide selectively homes to lymphatic vasculature of a tumor.
2. The isolated peptide of claim 1 , comprising the amino acid sequence CGNKRTRGC (SEQ ID NO: 1).
3. The isolated peptide of claim 1 or 2 , which is conformationally constrained.
4. The isolated peptide of claim 1 or 2 , which is cyclic.
5. The isolated peptide of claim 1 or 2 , which has a length of less than 100 residues.
6. The isolated peptide of claim 1 or 2 , which has a length of less than 50 residues.
7. The isolated peptide of claim 1 or 2 , which has a length of less than 20 residues.
8. The isolated peptide of claim 1 or 2 , which has a length of less than 15 residues.
9. The isolated peptide of claim 1 , wherein said peptide consists of the amino acid sequence GNKRTRG (SEQ ID NO: 2).
10. The isolated peptide of claim 2 , wherein said peptide consists of the amino acid sequence CGNKRTRGC (SEQ ID NO: 1).