Potassium channel modulators
This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SK Ca and/or IK Ca channels.
1. A compound according to Formula I
or any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable salt thereof, wherein
L 1 , L 2 , and L 3 are absent;
X and Y both represent a phenyl group, which phenyl group is substituted with halogen;
Z represents alkyl, alkenyl, alkynyl, or cycloalkyl; and
D represents —CN, R 6 —CN, or —CON(R 2 R 3 ), wherein
R 2 and R 3 , independently of each another, represent hydrogen or alkyl; and
R 6 represents alkyl.
2. The compound of claim 1 , which is
2-(2-Fluoro-phenyl)-2-(4-fluoro-phenyl)-pent-4-enenitrile;
2-(2-Fluoro-phenyl)-2-(4-fluoro-phenyl)-3-methyl-butyronitrile;
2,2-Bis-(4-fluoro-phenyl)-3-methyl-butyronitrile;
2,2-Bis-(4-fluoro-phenyl)-4-methyl-pentanenitrile;
2,2-Bis-(4-fluoro-phenyl)-pent-4-enenitrile;
2,2-Bis-(4-fluoro-phenyl)-pent-4-ynenitrile;
2-(2-Fluoro-phenyl)-2-(4-fluoro-phenyl)-pent-4-ynenitrile;
2-(2-Fluoro-phenyl)-2-(4-fluoro-phenyl)-4-methyl-pentanenitrile;
2-(3-Fluoro-phenyl)-2-(4-fluoro-phenyl)-3-methyl-butyronitrile;
2-(3-Fluoro-phenyl)-2-(4-fluoro-phenyl)-4-methyl-pentanenitrile;
2-(3-Fluoro-phenyl)-2-(4-fluoro-phenyl)-pent-4-enenitrile;
2-(3-Fluoro-phenyl)-2-(4-fluoro-phenyl)-pent-4-ynenitrile; or
2,2-Bis-(4-fluoro-phenyl)-3-methyl-butyramide;
or any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable salt thereof.
3. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically-acceptable addition salt thereof, together with at least one pharmaceutically-acceptable carrier or diluent.
4. The compound of claim 1 , wherein X and Y both represent a phenyl group substituted with fluoro or chloro.
5. The compound of claim 1 , wherein X and Y both represent a phenyl group substituted with fluoro.
6. The compound of claim 1 , wherein Z represents alkyl.
7. The compound of claim 1 , wherein D represents —CN.
8. The compound of claim 1 , wherein D represents —CON(R 2 R 3 ), wherein R 2 and R 3 , independently of each another, represent hydrogen or alkyl.
9. The compound of claim 1 , wherein D represents —CON(R 2 R 3 ), wherein R 2 and R 3 hydrogen.
10. The compound of claim 1 , which is 2,2-Bis-(4-fluoro-phenyl)-3-methyl-butyronitrile, or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 , which is 2,2-Bis-(4-fluoro-phenyl)-3-methyl-butyramide, or a pharmaceutically acceptable salt thereof.