IL4 receptor antagonists for horse, dog and cat
View Patent ↗The present application provides the horse, cat and dog IL4 receptor, including soluble receptors as well as method for therapeutic use of such receptors.
1. An isolated soluble IL-4 receptor polypeptide comprising a polypeptide having at least 70% amino acid sequence identity to the polypeptide of SEQ ID NO:4, wherein said isolated soluble IL4 receptor polypeptide binds IL4.
2. The isolated soluble IL4 receptor polypeptide of claim 1 comprising a polypeptide having at least 95% amino acid sequence identity to the polypeptide of SEQ ID NO:4.
3. A composition comprising the soluble IL4 receptor polypeptide of claim 1 , and a physiologically acceptable excipient.
4. The composition of claim 3 , wherein the soluble IL4 receptor polypeptide comprises a polypeptide having at least 95% amino acid sequence identity to the polyeptide of SEQ ID NO:4.
5. The isolated soluble IL4 receptor of claim 1 , wherein the IL4 receptor comprises SEQ ID NO:4.
6. An isolated IL4 receptor comprising the amino acid sequence selected from the group consisting of:
SEQ ID NO:2;
SEQ ID NO:2, except that the sequence includes the mutation A464V;
SEQ ID NO:2, except that the sequence includes the mutation A554S;
SEQ ID NO:2, except that the sequence includes the mutation A559T; and
SEQ ID NO:2, except that the sequence includes the mutation A572 V.