Granted Patent
B2
US 7,208,612 · App. 10/227,400 · Granted Apr 24, 2007
Crystals of LuxP and complexes thereof
Assignee:
Princeton University
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Abstract
A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.
Claims (1)
1. The isolated ligand having the chemical formula:
Assignments (5)
CONFIRMATORY LICENSE
Recorded May 31, 2017
From: PRINCETON UNIVERSITY
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 042630/0278 →
CONFIRMATORY LICENSE
Recorded May 15, 2017
From: PRINCETON UNIVERSITY
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 042465/0558 →
CONFIRMATORY LICENSE
Recorded May 15, 2017
From: PRINCETON UNIVERSITY
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 042497/0024 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 25, 2002
From: COOPER, STEPHEN R.
To: QUOREX PHARMACEUTICALS, INC.
Reel/Frame 013507/0169 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 25, 2002
From: BASSLER, BONNIE L.; SCHAUDER, STEPHAN; CHEN, XIN; HUGHSON, FREDERICK M.
To: PRINCETON UNIVERSITY
Reel/Frame 013508/0259 →
Continuity (2)
Provisional Application
6031470500
· Aug 24, 2001