NADP-dependent glyceraldehyde-3-phosphate dehydrogenase for therapeutic use
According to the present invention, a series of genes are identified in Group B Streptococcus , the products of which may be located on the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines for the immunization of a patient against microbial infection.
1. A method for raising antibodies against Group B Streptococcus , comprising administering an isolated Group B Streptococcal non-phosphorylating NADP-dependent glyceraldehydo-3-phosphate dehydrogenase to a subject, wherein the non-phosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase is administered in an amount effective to produce the antibodies.
2. The method, according to claim 1 , wherein the non-phosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase comprises SEQ ID NO:12.
3. The method according to claim 1 , wherein the subject is female.
4. The method according to claim 1 , wherein the subject is a pregnant female.
5. The method according to claim 2 , wherein the subject is female.
6. The method according to claim 2 , wherein the subject is a pregnant female.