Apparatus and method for delivery of an aerosol

1. An apparatus for measuring lung ventilation, comprising:

a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle;

a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle;

a computing device configured to provide lung ventilation data as a function of time constants;

and a coupling device configured to interact with the computing device and aerosol-generating device,

wherein coupling device is a 3-way valve.

2. The apparatus of claim 1 , wherein the aerosol particles have an average diameter of 0.05 microns to 1 micron.

3. The apparatus of claim 1 , wherein the aerosol particles have an average diameter of 0.1 microns to 0.8 microns.

4. The apparatus of claim 1 , wherein the aerosol particles have an average diameter of 0.1 microns to 0.6 microns.

5. The apparatus of claim 1 , wherein the pressure device comprises a filter, a pneumotachagraph, and a pressure transducer.

6. The apparatus of claim 1 , wherein the aerosol comprises one or more natural oils, one or more synthetic oils, or a blend of one or more natural and synthetic oils.

7. The apparatus of claim 1 , wherein the aerosol comprises corn oil, canola oil, MIGOYL or a mixture thereof.

8. An apparatus for measuring lung ventilation, comprising:

a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle;

a detector that measures the concentration of aerosol; particles for a given volume during the breathing cycle; and

a computing device configured to provide lung ventilation data as a function on time constants,

wherein the computing device comprises a means for controlling volume drift.

9. The apparatus of claim 8 , wherein the means for controlling volume drift is connected to a volume drift control switch.

10. The apparatus of claim 9 , wherein the volume drift control switch is connected to a mouthpiece.

11. The apparatus of claim 10 , wherein the mouthpiece further comprises a sensor switch.

12. The apparatus of claim 11 , wherein the sensor switch further comprises a proximity sensor.

13. An apparatus for measuring lung ventilation, comprising:

means for measuring pressure data; means for measuring concentration of aerosol particles;

means for providing an aerosol bolus at a determined point in a breathing cycle; and

means for collecting, computing, storing and displaying data,

wherein the computed data comprises a function of time constants and

wherein the means for computing data includes determining the point in the breathing cycle to inject the aerosol-bolus into an air flow.

14. A method for measuring lung ventilation, comprising: measuring pressure data and calculating volume of air flows for a plurality of respiratory cycles; calculating a volume of penetration; providing an aerosol bolus of particles at a determined point in a breathing cycle; measuring concentrations of aerosol particles; and calculating a distribution of time constants from the measured particle concentrations.

15. The method of claim 14 further comprising comparing the distribution of time constants from a patient diagnosed with a respiratory disease and a distribution of time constants predicted for a healthy individual.

16. The method of claim 14 wherein calculating volume of air flows comprises integrating the pressure data of a respiratory cycle as a function of time, and storing the volume data.

17. The method of claim 14 wherein the concentrations of aerosol particles are measured at provided points of a respiratory cycle following release of the aerosol bolus into the air flow.

18. The method of claim 17 , wherein the concentrations of aerosol particles are measured at provided points of an exhalation step of the respiratory cycle.

19. The method of claim 14 wherein calculating the distribution of time constants comprises analyzing particle concentration versus time, volume or dimensionless volume.

20. The apparatus of claim 13 , further comprises determining a total amount or percentage of a total amount of inhaled particulate material that is exhaled during a breath or in subsequent breaths after a breath in which the aerosol is inhaled.

21. The apparatus of claim 13 , wherein the aerosol particles are selected from one or more natural oils, one or more synthetic oils, or a blend of one or more natural and synthetic oils.