Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood flow. A method of treating visceral pain or visceral hypersensitivity in a human subject is also described. A method for prolonging the residence time of an orally or enterally administered substance by promoting its dissolution, bioavailability and/or absorption in the small intestine is also described. These methods are related to a method of transmitting to and replicating at a second location in the central nervous system a serotonergic neural signal originating at a first location in the proximal or distal gut of a mammal and/or a method of transmitting to and replicating at a second location in the upper gastrointestinal tract a serotonergic neural signal originating at a first location in the proximal or distal gut.
1. A method for treating obesity in a mammalian subject comprising administering peptide YY to said mammal.
2. The method of claim 1 wherein said subject is a human.
3. The method of claim 1 wherein said peptide YY is administered at a dose of about 0.8 micrograms (μg)/kg weight of said mammal/hour (hr).
4. The method of claim 3 wherein said peptide YY is administered by an oral or enteral delivery route.
5. The method of claim 3 wherein said peptide YY is administered by an oral delivery route.
6. A method of claim 1 wherein said peptide YY is administered parenterally.
7. The method of claim 6 wherein said peptide YY is administered at about 0.8 micrograms (μg)/kg weight of the mammal/hour(hr).
8. A method for treating obesity in a human subject comprising parenterally administering to said human peptide, peptide YY at a dose of about 0.8 micrograms (μg)/kg weight of the subject.
9. A method of inducing satiety in a mammalian subject comprising administering peptide YY to said mammalian subject.
10. The method of claim 9 wherein said peptide YY is administered at a dose of about 0.8 micrograms (μg)/kg weight of the subject.
11. The method of claim 10 wherein the peptide YY is administered by an oral or enteral route.
12. The method of claim 9 wherein said subject is a human.
13. The method of claim 9 wherein the peptide YY is administered parenterally.
14. The method of claim 13 wherein said peptide YY is administered at about 0.8 μg/kg weight of the subject/hr.