Method for providing long-lasting pain diminishment through topical or intranasal administration of civamide
A method of providing relatively long term diminishment or prevention of painful disorders comprises the topical or intranasal administration of civamide or one of its salts in an amount of about 0.001% to 1.0% by weight in a pharmaceutically acceptable vehicle over a relatively short term treatment period to provide unexpectedly long-lasting pain relief.
1. A method of providing relatively long term diminishment of pain from headaches comprising
(a) intranasally administering over a period of about five to fourteen days a composition of civamide (cis-8-methyl-N-vanillyl-6-nonenamide) or one of its salts in an amount of about 0.00 1% to 1% (weight/weight) in a phannaceutically acceptable vehicle, to achieve diminishment of pain,
(b) discontinuing said treatment of step (a) for a period of at least about three to six weeks, at least some diminishment of pain continuing through this period, and
(c) repeating the treatment of steps (a) and (b) upon the return of the pain.
2. A method of providing relatively long term diminishment of pain from arthritis, neuralgia, or neuropathy comprising
(a) topically administering over a period of about two weeks to four months a composition comprising civamide (cis-8-methyl-N-vanillyl-6-nonenaxnide) or one of its salts in an amount of about 0.001% to 1% (weight/weight) in a pharmaceutically acceptable vehicle, to achieve diminishment of the arthritis, neuralgia or neuropathic pain,
(b) discontinuing said treatment of step (a) for a period of at least about two to four months, at least some diminishment of pain continuing through this period, and
(c) repeating the treatment of steps (a) and (b) upon the return of the pain.
3. The method of claim 1 wherein said composition is administered intranasally over a period of about five to fourteen days and then discontinued, providing at least many weeks worth of continuing pain diminishment thereafter.
4. The method claim 2 wherein said composition is administered topically to the skin over a short period of about two weeks to several months and then discontinued, providing at least many weeks or months worth of continuing pain diminishment thereafter.