Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers
View Patent ↗The present invention provides methods for synthesizing novel tetrahydroquinoline derivatives that are useful for cancer chemotherapy and anti-viral applications. The present invention provides compounds useful for cancer chemotherapy and methods for the preparation of these compounds. The present invention also includes cancer chemotherapy methods.
1. A method of treating a cancer selected from the group consisting of lung cancer, CNS cancer, and breast cancer, by administering to a patient in need thereof a therapeutically effective amount of a compound having the formula:
wherein R 1 , R 2 , R 3 , R 4 , and R 5 are each independently selected from the group consisting of hydrogen, alkyl, phenyl, cyano, carboxy, hydroxy, alkoxy, phenyloxy, chloro, bromo, fluoro, iodo, amino, alkylamino, dialkylamino, phenylamino, and diphenylamino; and the number n is 1 or 2;
or a pharmaceutically acceptable salt thereof.
2. A method of treating a cancer selected from the group consisting of lung cancer, CNS cancer, and breast cancer by administering to a patient in need thereof a therapeutically effective amount of a compound having the formula:
wherein:
R 5 , R 10 , and R 11 are each, independently, selected from the group consisting of hydrogen, alkyl, and phenyl; and
n in each occurrence may be the same or different and is 1 or 2;
or a pharmaceutically acceptable salt thereof.
3. The method of claim 2 wherein the compound is in the form of a pharmaceutically acceptable salt.
4. The method of claim 2 wherein the compound is selected from the group consisting of: