IP Library › Granted Patent US 7,262,269
Granted Patent B2
US 7,262,269 · App. 10/682,659 · Granted Aug 28, 2007

Method for screening combinational bead library; ligands for cancer cells

Assignee: The Regents of University of California
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Quick Facts
Patent No.
US 7,262,269
App. No.
10/682,659
Granted
Aug 28, 2007
Kind
B2
Abstract

The invention includes a cell-growth-on-bead assay for screening a one-bead-one-compound combinatorial bead library to identify synthetic ligands for cell attachment and growth or proliferation of epithelial and non-epithelial cells. Cells are incubated with a compound bead library for 24 to 72-hours, allowing them to attach and grow on the beads. Those beads with cells growing are removed, and the ligand on the bead is identified. Also provided are ligands specific for cancer cells.

Claims (3)

1. A ligand specific for human epithelial cancer cells, wherein said ligand has the chemical structure of cDGLGDDc.

2. A ligand specific for human epithelial cancer cells, wherein said ligand has the chemical structure of c-d-G-HoCit-G-P-Q-c.

3. A ligand specific for human non-epithelial cancer cells, wherein said ligand has the chemical structure of cDGLGDDc.

Assignments (4)
CONFIRMATORY LICENSE Recorded Jun 2, 2011
From: UNIVERSITY OF CALIFORNIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 026381/0304 →
CONFIRMATORY LICENSE Recorded Feb 25, 2010
From: UNIVERSITY OF CALIFORNIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 023988/0188 →
EXECUTIVE ORDER 9424, CONFIRMATORY LICENSE Recorded Dec 18, 2008
From: UNIVERSITY OF CALIFORNIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022002/0046 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 8, 2003
From: LAM, KIT S.; LAU, DERICK H.
To: REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE
Reel/Frame 014598/0984 →
Continuity (2)
Continuation In Part 1003267800 · Oct 26, 2001
Related Publication 20040096906A1 · May 20, 2004