Method of treatment using Tie2 ligand2
The invention provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
1. A method of reducing ocular neovascularization in a human comprising administering to the human an agent capable of interfering with Tie2 ligand 2 binding to TIE1 or TIE2, such that ocular neovascularization is reduced, wherein the agent is a ligandbody comprising the fibrinogen-like domain of Tie2 ligand 2 beginning at position 281 to 496 of amino acid sequence of SEQ ID NO: 6 coupled to an Fc domain of IgG.
2. The method of claim 1 , wherein the ocular neovascularization is proliferative retinopathy or choroidal neovascularization.
3. The method of claim 2 , wherein the ocular neovascularization is lens neovascularization, corneal neovascularization, iridal neovascularization or conjunctival neovascularization.