Flumazenil for the treatment of alcohol dependency
The invention relates to the use of flumazenil in developing a drug used for the sequential administration of small quantities of flumazenil at short intervals, until a therapeutically effective quantity is administered to treat alcohol dependence.
1. A method to reduce a desire to drink alcohol in a patient having the desire to drink alcohol comprising administering an effective amount of flumazenil to the patient, wherein the flumazenil is administered sequentially in doses between about 0.1 and 0.3 mg of flumazenil at time intervals between about 1 and 15 minutes, wherein the amount of flumazenil is effective to reduce the desire to drink alcohol in the patient, and the effective amount of flumazenil is between about 1.5 and 2.5 mg/day.
2. The method of claim 1 , wherein the amount of flumazenil that is administered in each sequential administration is about 0.2 mg.
3. The method of claim 1 , wherein the flumazenil is administered at intervals of about 3 minutes.
4. The method of claim 1 , wherein the effective amount of flumazenil is about 2 mg/day.
5. The method of claim 1 , wherein the flumazenil is administered orally or parenterally.
6. The method of claim 5 , wherein the parenteral administration of flumazenil is intravenous administration.
7. The method of claim 1 , wherein the flumazenil is administered at doses of about 0.2 mg of flumazenil at intervals of about 3 minutes until an effective amount of flumazenil has been administered.
8. The method of claim 7 , wherein the effective amount is about 2 mg/day.
9. The method of claim 1 , wherein the flumazenil is administered before, during or after treatment with an additional agent.
10. The method of claim 9 , wherein the additional agent is selected from the group consisting of Vitamin B complex, vitamins, minerals, proteins, amino acids, fluoxetine, and combinations thereof.
11. The method of claim 1 , wherein the flumazenil is administered under sedation.