Polypeptide autoantigens associated with endometriosis
This invention provides a polynucleotide encoding Repro-EN-1.0 and IB1, polypeptides associated with endometriosis. Auto-antibodies against Repro-EN-1.0 and IB1 have been found in subjects diagnosed with endometriosis. This invention also provides methods of using this polynucleotide and polypeptide.
1. A purified, recombinant polypeptide comprising the amino acid sequence identical to that of SEQ ID NO:2, and comprising an epitope which specifically binds to antibodies from patients diagnosed with endometriosis.
2. A purified, recombinant polypeptide comprising the amino acid sequence identical to that of SEQ ID NO:4, and comprising an epitope which specifically binds to antibodies from patients diagnosed with endometriosis.
3. A purified, recombinant polypeptide comprising an amino acid sequence identical to that of amino acids 293 to 860 of SEQ ID NO:2, and comprising an epitope which specifically binds to antibodies from patients diagnosed with endometriosis.
4. A purified, recombinant polypeptide comprising the amino acid sequence identical to that of amino acids 293 to 937 of SEQ ID NO:4, and comprising an epitope which specifically binds to antibodies from patients diagnosed with endometriosis.