Granted Patent
B2
US 7,368,585 · App. 11/486,344 · Granted May 6, 2008
Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
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Abstract
Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
Claims (10)
1. A compound of formula:
wherein:
R 1 , R 2 , R 7 , and R 8 are independently C 1 -C 10 alkyl;
R 3 and R 6 are independently selected from hydrogen and C 1 -C 6 alkyl;
R 4 and R 9 are each independently an acid labile hydroxyl protecting group;
R 18 is C 6 -C 14 aryl;
R 25 is an acid stable hydroxyl protecting group; and
X is halogen.
2. The compound of claim 1 of formula:
wherein TBS is tert-butyldimethylsilyl, Ph is phenyl and PMB is para-methoxybenzyl.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Nov 9, 2022
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 061901/0941 →
CONFIRMATORY LICENSE
Recorded Apr 22, 2021
From: UNIVERSITY OF PENNSYLVANIA
To: NIH - DEITR
Reel/Frame 056009/0620 →
Continuity (6)