Indole derivatives substituted with long-chain alcohols and medicaments containing them
Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.
1. An indole long-chain alcohol, or a hydrate or an isomer thereof, according to the following formula (I):
wherein R 1 , R 2 , R 3 , and R 4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 10 to 20.
2. The indole long-chain alcohol according to claim 1 , wherein n represents a number from 12 to 20.
3. The indole long-chain alcohol according to claim 1 , wherein n represents a number from 14 to 20.
4. The indole long-chain alcohol according to claim 1 , wherein n represents a number from 16 to 20.
5. The indole long-chain alcohol according to claim 1 , wherein n represents a number from 18 to 20.
6. The indole long-chain alcohol according to claim 1 , wherein n represents a number from 10 to 14.
7. The indole long-chain alcohol according to claim 1 , wherein n represents a number from 12 to 16.
8. The indole long-chain alcohol according to claim 1 , wherein n represents a number from 14 to 18.
9. The indole long-chain alcohol according to claim 1 , wherein n is 10.
10. The indole long-chain alcohol according to claim 1 , wherein n is 12.
11. The indole long-chain alcohol according to claim 1 , wherein n is 14.
12. The indole long-chain alcohol according to claim 1 , wherein n is 16.
13. The indole long-chain alcohol according to claim 1 , wherein n is 18.
14. A medicinal composition comprising a therapeutically effective amount of the indole long-chain alcohol according to claim 1 and a pharmaceutically acceptable carrier.
15. The medicinal composition according to claim 14 , wherein the therapeutically effective amount of the indole long-chain alcohol is from 0.001 to 1000 mg.
16. The medicinal composition according to claim 14 , wherein the medicinal composition further comprises an excipient, a binder, a disintegrator, a lubricant, a colorant, and/or a corrigent.
17. The medicinal composition according to claim 14 , wherein the medicinal composition is in the form of a tablet, a coated tablet, a granule, a coated granule, a capsule, a solution, a syrup, an elixir, an oil suspension, or an aqueous suspension.
18. A method for treating a cerebral disease comprising administering to a patient in need thereof a therapeutically effective amount of the indole long-chain alcohol according to claim 1 , wherein the cerebral disease is a dementia disease.
19. The method according to claim 18 , wherein the therapeutically effective amount of the indole long-chain alcohol is from 0.001 to 1000 mg/day.
20. The method according to claim 18 , wherein the therapeutically effective amount of the indole long-chain alcohol is administered either once per day, or in two to four divided doses per day.
21. The method according to claim 18 , wherein the therapeutically effective amount of the indole long-chain alcohol is administered orally or parenterally.
22. A method for treating a malignant tumor comprising administering to a patient in need thereof a therapeutically effective amount of the indole long-chain alcohol according to claim 1 , wherein the malignant tumor is a brain tumor.
23. The method according to claim 22 , wherein the therapeutically effective amount of the indole long-chain alcohol is from 0.001 to 1000 mg/day.
24. The method according to claim 22 , wherein the therapeutically effective amount of the indole long-chain alcohol is administered either once per day, or in two to four divided doses per day.
25. The method according to claim 22 , wherein the therapeutically effective amount of the indole long-chain alcohol is administered orally or parenterally.
26. The indole long-chain alcohol according to claim 1 , wherein n is 20.