Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof
Disclosed are compounds having the formula wherein R 1 is hydrogen, an alkyl group, an aryl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an aralkyl group, or ═O, R 2 is an alkyl group, an aryl group, a cycloalkyl group, an alkenyl group, an alkynyl group, or an aralkyl group, or the pharmaceutically acceptable salt or ester thereof. Also disclosed are methods of using the compounds.
1. A compound having the formula
wherein R 1 is an alkenyl group, an alkynyl group, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, benzene, naphthalene, benzyl, or 2-hydroxyphenyl, or the pharmaceutically acceptable salt or ester thereof.
2. A compound having the formula
wherein R 1 is an alkyl group, an alkenyl group, an alkynyl group, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, benzene, naphthalene, benzyl, or 2-hydroxyphenyl,
R 2 is an alkyl group, an alkenyl group, an alkynyl group, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, benzene, naphthalene, benzyl, or 2-hydroxyphenyl;
or the pharmaceutically acceptable salt or ester thereof.