Mono di & tri cyclic compounds useful for lowering IgE concentrations
View Patent ↗The present invention is directed novel compounds which are derivatives of minocycline or doxycycline, pharmaceutical compositions containing same and use thereof in lowering excess IgE levels in a mammal suffering from a disease where IgE is pathogenic.
1. A compound having the formula
2. A pharmaceutical composition comprising a pharmaceutically effective amount of a compound of claim 1 and a pharmaceutical carrier therefor.
3. A method of lowering the IgE concentration in the plasma of a mammal having a higher then normal concentration of IgE in its plasma comprising administering thereto a therapeutically effective amount of a compound of claim 1 .
4. A method of treating a subject suffering from a disease or condition selected from a group consisting of allergy or inflammatory condition or asthma—has been characterized by excess IgE concentration in the plasma of said subject comprising administering to said subject a therapeutically effective amount of a compound of claim 1 .
5. The method according to claim 4 wherein the subject matter is a mammal.
6. The method according to claim 4 wherein the mammal is a human.