IP Library › Granted Patent US 7,429,267
Granted Patent B2
US 7,429,267 · App. 10/496,476 · Granted Sep 30, 2008

Device and method using integrated neuronal cells and an electronic device

Assignee: The Trustees of the University of Pennsylvania
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Quick Facts
Patent No.
US 7,429,267
App. No.
10/496,476
Granted
Sep 30, 2008
Kind
B2
Abstract

The present invention provides a device of integrated neuronal cells interfaced with an electronic device and a method of producing the same.

Claims (12)

1. A device comprising a first isolated neuronal cell, a second isolated neuronal cell, and an electronic device, wherein the first isolated neuronal cell is interfaced with the electronic device and wherein the first isolated neuronal cell is integrated to the second isolated neuronal cell via elongated axons greater than 1 cm in length.

2. The device of claim 1 , wherein the elongated axons greater than 3 cm in length.

3. The device of claim 1 , wherein the neuronal cells transmit an electrical signal to the electronic device.

4. The device of claim 1 , wherein the neuronal cells receive an electrical signal from the electronic device.

5. The device of claim 1 , wherein the integrated neuronal cells comprise fascicular axon tracts.

6. A method of producing a device comprising integrated neuronal cells interfaced with an electronic device comprising placing a first isolated neuronal cell on an electronic device, thereby interfacing the first isolated neuronal cell with the electronic device, placing a second isolated neuronal cell on a membrane adjacent to said electronic device, integrating the first isolated neuronal cell with the second isolated neuronal cell to produce integrated neuronal cells interfaced with an electronic device and separating said electronic device from said membrane, thereby producing elongated axons greater than 1 cm in length.

7. The method of claim 6 further comprising separating said electronic device from said membrane using a micro-stepper motor system.

8. The device of claim 1 , wherein the second isolated neuronal cell is attached to an implantable membrane.

9. The device of claim 1 , wherein the electronic device is a multi-electrode array.

10. The device of claim 1 , wherein said first isolated neuronal cell comprises a first population of isolated neuronal cells.

11. The device of claim 1 , wherein said second isolated neuronal cell comprises a second population of isolated neuronal cells.

12. The device of claim 10 , wherein said second isolated neuronal cell comprises a second population of isolated neuronal cells.

Assignments (4)
CONFIRMATORY LICENSE Recorded Mar 14, 2013
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 029993/0236 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CORRECTIVE ASSIGNMENT TO CORRECT MIDDLE INITIAL OF ASSIGNOR DOUGLAS HAMILTON SMITH - MIDDLE NAME WAS INADVERTENTLY TYPED AS "R". PREVIOUSLY RECORDED ON REEL 017173 FRAME 0961. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNOR SMITH'S NAME WAS CORRECTLY NOTED IN THE ASSIGNMENT EXECUTED ON OCTOBER 5, 2005 A COPY OF WHICH IS ATTACHED HERETO. Recorded Jun 15, 2006
From: SMITH, DOUGLAS HAMILTON; PFISTER, BYRAN J.; MEANEY, DAVID F.
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 017796/0161 →
CORRECTIVE ASSIGNMENT TO CORRECT THE SPELLING OF ASSIGNOR DOUGLAS HAMILTON SMITH - LAST NAME IS INCORRECTLY NOTED AS 'SMTH' AND SHOULD BE 'SMITH' PREVIOUSLY RECORDED ON REEL 017173 FRAME 0961. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNOR SMITH'S NAME WAS CORRECTLY NOTED IN THE ASSIGNMENT EXECUTED ON OCTOBER 5, 2005 A COPY OF WHICH IS ATTACHED HERETO.. Recorded Jun 9, 2006
From: SMITH, DOUGLAS R.; PFISTER, BYRAN J.; MEANEY, DAVID F.
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 017752/0846 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 4, 2005
From: SMTH, DOUGLAS HAMILTON; PFISTER, BRYAN; MEANEY, DAVID F.
To: TRUSTEES OF THE UNIVERSTIY OF PENNSYLVANIA, THE
Reel/Frame 017173/0961 →
Continuity (3)
Provisional Application 6038698200 · Jun 6, 2002
Provisional Application 6033697500 · Dec 4, 2001
Related Publication 20050070960A1 · Mar 31, 2005