Drugs for spinal anesthesia
Spinal anesthetics for intrathecal administration to produce spinal anesthesia are provided with use of 6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinolone-3-carboxylic acid or its pharmaceutically active analogues.
1. A method of inducing spinal anesthesia, comprising:
administering spinally an anesthesia producing effective amount of 6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinolone-3-carboxylic acid to a patient in need of spinal anesthetic.
2. The method of claim 1 wherein the administering spinally is by intrathecal administration.
3. The method of claim 1 wherein the 6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinolone-3-carboxylic acid is administered in conjunction with a pharmaceutically acceptable carrier.
4. The method of claim 2 wherein the 6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinolone-3-carboxylic acid is administered in conjunction with a pharmaceutically acceptable carrier.
5. The method of claim 1 wherein the amount of 6-[2-(1(2)H -tetrazole-5-yl)ethyl]decahydroisoquinolone-3-carboxylic acid administered is from 0.1 mg to 3.0 mg.
6. The method of claim 1 wherein the amount of 6-[2-(1(2)H -tetrazole-5-yl)ethyl]decahydroisoquinolone-3-carboxylic acid administered is from 0.5 mg to 2.0 mg.
7. The method of claim 1 wherein the 6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoqui nolone-3-carboxylic acid is LY293558 ((3S,4aR,6R,8aR)6- [2-1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinolone-3-carboxylic acid).
8. The method of claim 2 wherein the 6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinolone-3-carboxylic acid is LY293558 ((3S,4aR,6R,8aR)6- [2-1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinolone-3-carboxylic acid).