Controlled synthesis of highly monodispersed gold nanoparticles
View Patent ↗A method of synthesizing highly monodispersed Au nanoparticles having diameters in the range of 30-90 nm. Seed nanoparticles in a controlled concentration are combined with a precursor, also in a controlled concentration, a reducing and capping agent (e.g., sodium acrylate) in aqueous solution. Under controlled conditions of pH, temperature, and time, highly monodispersed nanoparticles having diameters in the range of 30-100 nm are produced. A relative size standard deviation of the size distribution of the resulting nanoparticles is as low as 2%.
1. A method of preparing highly monodispersed gold nanoparticles, said method comprising:
a) providing seed nanoparticles;
b) combining said seed nanoparticles with a gold precursor;
c) combining an acrylate reducing and capping agent with said combination of said seed nanoparticles and said gold precursor to form a reaction mixture; and
d) growing highly monodispersed gold nanoparticles from the reaction mixture at a temperature of up to 30° C., wherein the monodispersed gold nanoparticles have a size distribution with a relative standard deviation of less than 5% and a diameter of 30-100 nm.
2. The method of preparing highly monodispersed gold nanoparticles as recited in claim 1 , wherein said gold precursor comprises AuCl 4 − .
3. The method of preparing highly monodispersed gold nanoparticles as recited in claim 1 , wherein said seed nanoparticles have a diameter in the range of 30 to 62 nm.
4. The method of preparing highly monodispersed gold nanoparticles as recited in claim 1 , wherein a concentration of seed nanoparticles is within the range of 1×10 10 to 2×10 11 particles/mL.
5. The method of preparing highly monodispersed gold nanoparticles as recited in claim 1 , wherein a concentration of the gold precursor in said combination of said seed nanoparticles and said gold precursor is within the range of 0.05 to 0.2 M.
6. The method of preparing highly monodispersed gold nanoparticles as recited in claim 1 , wherein said combination of said seed nanoparticles and said gold precursor is controlled to a pH within the limits of 6.5 to 7.5.
7. The method of preparing highly monodispersed gold nanoparticles as recited in claim 1 , the steps further comprising:
e) centrifuging the reaction mixture containing said resultant nanoparticles.
8. A method of preparing highly monodispersed gold nanoparticles, the steps comprising:
a) providing seed nanoparticles;
b) combining said seed nanoparticles with a gold precursor;
c) combining an acrylate reducing and capping agent with said combination of said seed nanoparticles and said gold precursor to form a reaction mixture;
d) growing highly monodispersed gold nanoparticles from the reaction mixture at a temperature of up to 30° C., wherein the monodispersed gold nanoparticles have a size distribution with a relative standard deviation of less than 5% and a diameter of 30-100 nm; and
e) repeating steps b), c), and d) using the gold nanoparticles resulting from said growing.
9. The method of preparing highly monodispersed gold nanoparticles as recited in claim 8 , wherein said gold precursor comprises AuCl 4 − .
10. The method of preparing highly monodispersed gold nanoparticles as recited in claim 8 , wherein said seed nanoparticles have a diameter in the range of 30 to 62 nm.
11. The method of preparing highly monodispersed gold nanoparticles as recited in claim 8 , wherein a concentration of seed nanoparticles is within the range of 1×10 10 to 2×10 11 particles/mL.
12. The method of preparing highly monodispersed gold nanoparticles as recited in claim 8 , wherein a concentration of the gold precursor in said combination of said seed nanoparticles and said gold precursor is within the range of 0.05 to 0.2 M.
13. The method of preparing highly monodispersed gold nanoparticles as recited in claim 8 , wherein said combination of said seed nanoparticles and said gold precursor is controlled to a pH within the limits of 6.5 to 7.5.
14. The method of preparing highly monodispersed gold nanoparticles as recited in claim 8 , the steps further comprising:
f) centrifuging the reaction mixture containing said resultant nanoparticles.
15. The method of preparing highly monodispersed gold nanoparticles as recited in claim 1 , wherein the reaction mixture temperature is from 4° C. to 30° C.
16. The method of preparing highly monodispersed gold nanoparticles as recited in claim 1 , wherein the monodispersed gold nanoparticles have a size distribution with a relative standard deviation of 2-5%.
17. The method of preparing highly monodispersed gold nanoparticles as recited in claim 8 ,wherein the reaction mixture temperature is from 4° C. to 30° C.
18. The method of preparing highly monodispersed gold nanoparticles as recited in claim 8 , wherein the monodispersed gold nanoparticles have a size distribution with a relative standard deviation of 2-5%.