Granted Patent
B2
US 7,531,314 · App. 11/499,393 · Granted May 12, 2009
Therapeutic and diagnostic applications of perlecan domain I splice variants
Assignee:
University of Washington
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Abstract
A method of producing antibodies comprising the step of encoding a peptide sequence from a Domain I perlecan splice variant, wherein the peptide sequence is used to produce anti-peptide antibodies.
Claims (6)
1. An in vitro method for verifying presence or quantifying extent of Alzheimer's type neurofibrillary tangles and amyloid plaques in a patient, the method comprising:
(a) producing a peptide-consisting of SEQ ID NO: 16;
(b) producing an antibody to the peptide;
(c) radiolabeling the antibody;
(d) administering the radiolabeled antibody to the patient;
(e) detecting and quantifying the binding of the radiolabeled antibody to determine the extent of neurofibrillary tangles and amyloid plaques in the patient.
Assignments (4)
CONFIRMATORY LICENSE
Recorded Aug 28, 2019
From: UNIVERSITY OF WASHINGTON
To: NATIONAL INSTITUTES OF HEALTH (NIH)
Reel/Frame 050204/0522 →
CONFIRMATORY LICENSE
Recorded Sep 22, 2009
From: UNIVERSITY OF WASHINGTON
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 023262/0749 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 26, 2007
From: MARESH GRACE
To: WASHINGTON, UNIVERSITY OF
Reel/Frame 020965/0725 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 26, 2007
From: SNOW ALAN
To: WASHINGTON, UNIVERSTIY OF
Reel/Frame 020969/0388 →
Continuity (2)