Stable organic peroxide compositions
Methods of treating acne include the use of formulations including a benzoyl peroxide solution and an antioxidant.
1. A method of treating acne comprising:
combining an antioxidant with benzoyl peroxide and a solvent system containing an aryl benzoate ester to provide a stable peroxide solution;
formulating a product suitable for topical application to the skin containing the stable peroxide solution; and
applying the product to the skin of a subject afflicted with acne.
2. The method of claim 1 wherein the benzoyl peroxide and solvent are combined with an antioxidant selected from the group consisting of butylated hydroxyl toluene (BHT), butylated hydroxyanisole (BHA), vitamin E acetate, ascorbyl palmitate, tetrahydrocurcuminoids, t-butyl hydroquinone, meta and para cresols and phenolics.
3. The method of claim 1 wherein formulating a product comprises adding an aqueous phase to the peroxide solution to form an emulsion.
4. The method of claim 3 , wherein the aqueous phase added to form an emulsion comprises a surfactant, a humectant and a suspending agent.
5. The method of claim 1 wherein the product formulated is one of a solution, emulsion, suspension, cream, lotion, gel, or powder.
6. The method of claim 1 wherein the peroxide solution comprises less than 2% antioxidant by weight of the solution, and no more than about 10% benzoyl peroxide.
7. The method of claim 1 further comprising adding a thickener.
8. A method of treating acne comprising applying a composition comprising benzoyl peroxide, a solvent system comprising an aryl benzoate ester, and an antioxidant to the skin of a user afflicted with acne.
9. The method of claim 8 wherein the composition applied is a solution comprising between about 5 to 10% antioxidant by weight of the composition, and no more than about 20% benzoyl peroxide by weight of the composition.
10. The method of claim 8 wherein the composition applied further comprises a secondary solvent.
11. The method of claim 8 wherein the composition applied further comprises a secondary solvent selected from the group consisting of dimethyl isosorbide, and glycol ethers of C 1 to C 6 alcohols with no greater than 2 moles of ethylene oxide.
12. The method of claim 8 wherein the composition applied further comprises a rheology modifier.