IP Library › Granted Patent US 7,560,265
Granted Patent B2
US 7,560,265 · App. 10/578,943 · Granted Jul 14, 2009

Compositions for regulation of tumor necrosis factor-alpha

Assignee: The Regents of the University of Colorado, a body corporate
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Quick Facts
Patent No.
US 7,560,265
App. No.
10/578,943
Granted
Jul 14, 2009
Kind
B2
Abstract

The present invention relates to compositions relating a nucleic acid encoding an interleukin 18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In particular, the present invention provides vectors for expressing proteins useful for treating autoimmune diseases and cancer, in part by regulation of tumor necrosis factor-alpha expression.

Claims (5)

1. An isolated nucleic acid comprising SEQ ID NO:15.

2. The nucleic acid of claim 1 , wherein said nucleic acid comprises SEQ ID NO:3.

3. The nucleic acid of any one of claims 1 or 2 , wherein said nucleic acid is operably linked to a heterologous promoter.

4. A vector comprising the nucleic acid of claim 3 .

5. A host cell comprising the vector of claim 4 .

Assignments (5)
CONFIRMATORY LICENSE Recorded Jan 17, 2019
From: THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE
To: NIH - DIETR
Reel/Frame 048049/0621 →
CONFIRMATORY LICENSE Recorded Oct 23, 2012
From: UNIVERSITY OF COLORADO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 029177/0308 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF THE ASSIGNEE PARTY PREVIOUSLY RECORDED ON REEL 022422 FRAME 0717. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNORS' SIGNATURES. Recorded Mar 24, 2009
From: KIM, SOO-HYUN; DINARELLO, CHARLES A.; AZAM, TANIA
To: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Reel/Frame 022445/0574 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE'S ADDRESS PREVIOUSLY RECORDED ON REEL 018493 FRAME 0737. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNORS'SIGNATURES. Recorded Mar 19, 2009
From: KIM, SOO-HYUN; DINARELLO, CHARLES A.; AZAM, TANIA
To: THE REGENTS OF THE UNIVERSITY OF COLORADO
Reel/Frame 022422/0717 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2006
From: KIM, SOO-HYUN; DINARELLO, CHARLES A.; AZAM, TANIA
To: REGENTS OF THE UNIVERSITY OF COLORADO, THE
Reel/Frame 018493/0737 →
Continuity (2)
Provisional Application 6051981800 · Nov 12, 2003
Related Publication 20070071719A1 · Mar 29, 2007