Method for stimulating the immune, inflammatory or neuroprotective response
View Patent ↗Cycic di-GMP, or a cyclic dinucleotide analogue thereof that has the same effect as cyclic di-GMP, stimulates or enhances immune or inflammatory response in a patient or enhances the immune response to a vaccine by serving as an adjuvant. Cyclic di-GMP, or a cyclic dinucleotide analogue thereof, also has neuroprotective properties for use as a neuroprotective agent to inhibit, treat, or ameliorate the effects of injuries, diseases, disorders or conditions that result in neurodegeneration.
1. A method for modulating immune or inflammatory response in a patient, comprising administering an effective amount of cyclic di-GMP or a cyclic dinucleotide analogue thereof to a patient in need thereof to modulate the immune or inflammatory response.
2. The method of claim 1 , comprising administering an effective amount of cyclic di-GMP or a cyclic dinucleotide analogue thereof to a patient in need thereof to stimulate or enhance the immune or inflammatory response in the patient.
3. The method of claim 2 , wherein an effective amount of cyclic di-GMP is administered to the patient in need thereof.
4. The method of claim 2 , wherein an effective amount of a cyclic dinucleotide analogue is administered to the patient in need thereof.
5. The method of claim 4 , wherein said cyclic dinucleotide analogue thereof is selected from the group consisting of cyclic dinucleotide compounds (I)-(XX)
6. The method of claim 2 , wherein the immune response stimulated or enhanced includes a Th1 oriented immune response.
7. The method of claim 2 , which enhances immune response to a vaccine, wherein an effective amount of a vaccine or antigen is administered to the patient in need thereof in combination with an effective amount of cyclic di-GMP or a cyclic dinucleotide analogue thereof.
8. The method of claim 7 , wherein the immune response is a cellular response.
9. The method of claim 7 , wherein the vaccine is selected from the group consisting of a protein vaccine, a polysaccharide vaccine, a DNA vaccine, a live attenuated vaccine, and a killed vaccine.
10. A method for inhibiting neuronal degeneration, comprising administering to a patient in need thereof an effective amount of cyclic di-GMP or a cyclic dinucleotide analogue thereof to inhibit neuronal degeneration in the patient.
11. The method of claim 10 , wherein an effective amount of cyclic di-GMP is administered to the patient in need thereof.
12. The method of claim 10 , wherein an effective amount of a cyclic dinucleotide analogue is administered to the patient in need thereof.
13. The method of claim 12 , wherein said cyclic dinucleotide analogue thereof is selected from the group consisting of cyclic dinucleotide compounds (I)-(XX)
14. The method of claim 1 , comprising administering an effective amount of cyclic di-GMP or a cyclic dinucleotide analogue thereof to a patient in need thereof to inhibit an allergic reaction.
15. The method of claim 14 , wherein an effective amount of cyclic di-GMP is administrated to the patient in need thereof.
16. The method of claim 14 , wherein an effective amount of a cyclic dinucleotide analogue of cyclic di-GMP is administered to the patient in need thereof.
17. The method of claim 16 , wherein said cyclic dinucleotide analogue is selected from the group consisting of cyclic dinucleotide compounds (I)-(XX)