Method for the diagnosis of sepsis with determination of CA 19-9
Method for early differential diagnosis and detection, prognosis and assessment of the severity and therapy-accompanying assessment of the course of sepsis and sepsis-like systemic infections, in which, preferably with determination of at least one further parameter suitable for sepsis diagnosis, the amount of CA 19-9 in a biological fluid of a patient who is suffering from sepsis or is suspected of having sepsis is determined and conclusions are drawn from the determined amount of CA 19-9 with regard to the presence, the expected course, the severity and/or the success of initiated measures for the treatment of the sepsis.
1. A method for assisting in the diagnosis of sepsis, said method comprising testing a biological fluid of a patient who, based on clinical findings, has sepsis-associated symptoms, for an elevated amount of CA19-9 as compared to a control group, wherein an elevated amount of CA19-9 in said sample is indicative of sepsis.
2. The method of claim 1 , wherein the elevated amount of CA19-9 is determined by an immunodiagnostic assay method.
3. The method of claim 1 , wherein said method is carried out in the course of a multiparameter determination in which at the same time at least one further sepsis parameter is determined.
4. The method of claim 3 , wherein said at least one further sepsis parameter determined in the course of the multiparameter determination is selected from the group consisting of procalcitonin, CA125, S100B, S100A proteins, CYFRA 21, TPS, soluble cytokeratin-1 fragments (sCY1F), inflammin, CHP, peptide prohormones and the C-reactive protein (CRP).
5. The method of claim 3 , wherein said multiparameter determination is carried out as a simultaneous determination using a measuring apparatus operating according to the chip technology or immunochromatographic method.
6. The method according to claim 5 , wherein said measuring apparatus provides a complex measured result and wherein the evaluation of said complex measured result is carried out using a computer program.
7. The method of claim 1 , wherein said biological fluid is serum.
8. The method of claim 1 , wherein said sepsis is a bacterial sepsis.
9. The method of claim 3 , wherein said method is carried out in the course of a multiparameter determination in which at the same time other sepsis parameters are determined, and a result in the form of a set of measured variables is obtained and evaluated for sepsis diagnosis.