Multi-action anthelmintic formulations
View Patent ↗The present invention provides a method for preparing a pharmaceutical formulation containing ivermectin and a method and composition that can contain ivermectin plus tetrahydropyrimidines. An examples of a tetrahydropyrimidine includes pyrantel. A pharmaceutical formulation is provided for use in the treatment of helminthiasis of mammals, and particularly tapeworm, hookworm, roundworm and heartworm of domestic animals and farm animals. The present invention also provides a method of treating helminthiasis in mammals, which method comprises administering to the mammal in need thereof an anthelmintically effective amount of a pharmaceutical formulation of the invention.
1. A method for forming an anthelmintic formulation comprising the steps of:
preparing a combination of ivermectin, an alcohol, and a second material, wherein the second material comprises polyethylene glycol; then
spray granulating the combination to form granules, with the polyethylene glycol covering the ivermectin, and
combining the granules with an additional active ingredient composition.
2. The method of claim 1 , wherein the additional ingredient composition consists essentially of a pyrantel or pyrantel pamoate.
3. The method of claim 1 , comprising adding an anthelmintic pyrimidine to the formulation.
4. The method of claim 1 , wherein the formulation is pressed into a tablet or enclosed in a capsule and the ivermectin has been effectively isolated, so that the formulation will stay stable for over one month.
5. The method of claim 1 , wherein the spray granulating step maintains the ivermectin stable for over one month.
6. A method for forming an anthelmintic formulation, comprising the steps of:
a) preparing a first preparation comprising an avermectin, polyethylene glycol, and water;
b) preparing a second preparation comprising a tetrahydropyrimidine and water, wherein the avermectin and tetrahydropyrimidine preparations together comprise an anthelmintic combination
c) separately forming solids from the first and second preparations, said solid forming step comprising spray granulating the first preparation with the polyethylene glycol covering the avermectin; and
d) combining the solid preparations to form an anthelmintic solid, consisting essentially of the avermectin and the tetrahydropyrimidine, with one or more appropriate excipients to provide the combinations in a form suitable to be administered to a mammal.
7. The method of claim 6 , wherein the anthelmintic combination comprises ivermectin.
8. The method of claim 6 , wherein the anthelmintic combination comprises at least about 0.005% ivermectin.
9. The method of claim 6 , wherein the anthelmintic combination comprises about 0.012-5% ivermectin.
10. The method of claim 6 , wherein the anthelmintic combination comprises pyrantel pamoate.
11. The method of claim 6 , wherein the anthelmintic combination comprises at least about 1.5% pyrantel pamoate.
12. The method of claim 6 , wherein the anthelmintic combination comprises about 11.2-23% pyrantel pamoate.
13. The method of claim 6 , wherein the solid forming step comprises spray granulating ivermectin.
14. A method for forming an anthelmintic formulation comprising the steps of:
a) preparing a first preparation comprising an avermectin, polyethylene glycol and an alcohol;
b) preparing a second preparation comprising a tetrahydropyrimidine and an alcohol, wherein the avermectin and tetrahydropyrimidine preparations together comprise an anthelmintic combination
c) separately forming solids from the first and second preparations, said solid forming step comprising spray granulating the first preparation with the polyethylene glycol covering the avermectin; and
d) combining the solid preparations to form an anthelmintic solid, consisting essentially of the avermectin and the tetrahydropyrimidine, with one or more appropriate excipients to provide the combinations in a form suitable to be administered to a mammal.
15. The method of claim 14 , wherein the anthelmintic combination comprises ivermectin.
16. The method of claim 14 , wherein the anthelmintic combination comprises at least about 0.005% ivermectin.
17. The method of claim 14 , wherein the anthelmintic combination comprises about 0.012-5% ivermectin.
18. The method of claim 14 , wherein the anthelmintic combination comprises pyrantel pamoate.
19. The method of claim 14 , wherein the anthelmintic combination comprises at least about 1.5% pyrantel pamoate.
20. The method of claim 14 , wherein the anthelmintic combination comprises about 11.2-23% pyrantel pamoate.
21. The method of claim 14 , wherein the alcohol is selected from the group consisting of ethanol, butanol, benzyl alcohol, and isopropanol.
22. The method of claim 14 , wherein the solid forming step comprises spray granulating ivermectin.