Pharmaceutical use of water-soluble fraction of
View Patent ↗A pharmaceutical composition containing a water-soluble fraction of Graptopetalum and its use in treating a liver disease or condition, such as inflammation, steatosis, and fibrosis.
1. A method of treating a subject suffering from or susceptible to a liver disease or medical condition, comprising administering an effective amount of a pharmaceutical composition comprising a water-soluble fraction of Graptopetalum to the subject, wherein the liver disease or medical condition is selected from the group consisting of liver inflammation, liver steatosis, liver fibrosis, liver cirrhosis, and hepatitis.
2. The method according to claim 1 , wherein the water-soluble fraction of Graptopetalum is an aqueous Graptopetalum extract.
3. The method according to claim 1 , wherein the Graptopetalum is Graptopetalum paraguayense.
4. The method according to claim 1 , wherein the liver disease or medical condition is liver inflammation.
5. The method according to claim 1 , wherein the liver disease or medical condition is liver steatosis.
6. The method according to claim 1 , wherein the liver disease or medical condition is liver fibrosis.
7. The method according to claim 1 , wherein the liver disease or medical condition is liver cirrhosis.
8. The method according to claim 1 , wherein the liver disease or medical condition is hepatitis.
9. The method according to claim 8 , wherein the hepatitis is hepatitis B.
10. The method according to claim 1 , wherein the pharmaceutical composition is administered orally.
11. The method according to claim 2 , wherein the aqueous Graptopetalum extract is prepared by:
(a) freeze drying a whole Graptopetalum plant to form a dried Graytopetalum plant;
(b) grinding the dried Graptopetalum plant to form a Graptopetalum powder;
(c) lyophilizing the Graptopetalum powder to produce a lyophilized powder;
(d) extracting the lyophilized powder with water to obtain a Graptopetalum extract; and
(e) lyophilizing the Graptopetalum extract.
12. The method according to claim 11 , wherein the Graptopetalum is Graptopetalum paraguayense.
13. The method according to claim 11 , wherein the liver disease or medical condition is liver inflammation.
14. The method according to claim 11 , wherein the liver disease or medical condition is liver steatosis.
15. The method according to claim 11 , wherein the liver disease or medical condition is liver fibrosis.
16. The method according to claim 11 , wherein the liver disease or medical condition is liver cirrhosis.
17. The method according to claim 11 , wherein the liver disease or medical condition is hepatitis.
18. The method according to claim 17 , wherein the hepatitis is hepatitis B.
19. The method according to claim 11 , wherein the pharmaceutical composition is administered orally.