Inhibitors of protein kinases
The present invention is directed to a compound having the formula wherein R 1 , R 2 , R 3 , R 4 , G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to compounds that stabilize the open conformation of a protein kinase, a crystallized protein kinase in the open conformation, and uses thereof. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease.
1. A compound selected from the group consisting of
1-[5-tert-butyl-3-(1,1-dioxo-1λ 6 -[1,2,5]thiadiazepane-5-carbonyl)thiophen-2-yl]-3-[4-(pyridin-4-yloxy)phenyl]urea;
1-[5-tert-butyl-3-(3-oxo-piperazine-1-carbonyl)thiophen-2-yl]-3-[4-(pyridin-4-yloxy)phenyl]urea;
1-[5-tert-butyl-3-(1,1-dioxo-1λ 6 -thiomorpholine-4-carbonyl)thiophen-2-yl]-3-[4-(pyridin-4-yloxy)phenyl]urea; and
1-[5-tert-butyl-3-(5-oxo-[1,4]diazepane-1-carbonyl)thiophen-2-yl]-3-[4-(pyridin-4-yloxy)phenyl]urea;
or pharmaceutically acceptable salt thereof.