Granted Patent B2

US 7,618,937 · App. 11/280,107 · Granted Nov 17, 2009

Assignee: Northwestern University

Abstract

Claims (24)

1. A peptidomimetic polymer comprising a polypeptide and a polypeptoid, the polypeptide having the structure:

the polypeptoid having the structure:

wherein R 1 comprises at least one dihydroxyphenyl alone or in combination with an amine-terminated lower alkyl chain having from 1 to about 10 carbon atoms;

wherein R 2 comprises at least one ether linkage, wherein each alkyl group or chain of the ether has from 1 to about 10 carbon atoms; n 1 has a value in the range of about 1 to about 10; and n 2 has a value in the range of about 5 to about 100.

2. A peptidomimetic polymer according to claim 1 wherein R 1 comprises

3. A peptidomimetic polymer according to claim 1 wherein

R 2 is —CH 2 —CH 2 —O—CH 3 .

4. A peptidomimetic polymer according to claim 1 wherein n 1 is 3.

5. A peptidomimetic polymer according to claim 1 wherein n 2 is 20.

6. A coating comprising a peptidomimetic polymer comprising a polypeptide and a polypeptoid, the polypeptide having the structure:

the polypeptoid having this structure:

wherein R 1 comprises at least one dihydroxyphenyl alone or in combination with an amine-terminated lower alkyl chain having from 1 to about 10 carbon atoms;

wherein R 2 comprises at least one ether linkage, wherein each alkyl group or chain of the ether has from 1 to about 10 carbon atoms;

n 1 has a value in the range of about 1 to about 10; and

n 2 has a value in the range of about 5 to about 100.

7. A coated metal work piece comprising a metal substrate having adhered thereto the peptidomimetic polymer coating of claim 6 .

8. A work piece according to claim 7 wherein the metal substrate is a working surface of a medical device.

9. A work piece according to claim 7 wherein the metal substrate comprises titanium oxide.

10. An antifouling resistant coating comprising a polypeptidomimetic polymer comprising an anchoring polypeptide and an antifouling polypeptoid, the anchoring polypeptide having the structure:

the antifouling polypeptoid having the structure:

wherein R 1 comprises at least one dihydroxyphenyl alone or in combination with an amine-terminated lower alkyl chain having from 1 to about 10 carbon atoms;

wherein R 2 comprises at least one ether linkage, wherein each alkyl group or chain of the ether has from 1 to about 10 carbon atoms;

n 1 ranges from about 1 to about 10; and

n 2 ranges from about 5 to about 100.

Assignments (2)

Continuity (9)