Compositions and methods relating to novel benzodiazepine compounds and derivatives
View Patent ↗The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
1. A compound described by the following formula:
including both R and S enantiomeric forms and racemic mixtures;
R 14 and R 15 are selected from the group consisting of hydrogen and CH 3 ; and R 11 is OH;
wherein R 4 is CH 3 or a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons; and
wherein R 5 is
wherein R 17 is hydrogen, halogen, or CH 3 .
2. The compound of claim 1 , wherein R 3 is selected from
the group consisting of:
wherein R 12 , R 13 , R 14 and R 15 are selected from the group consisting of hydrogen and CH 3 ; and R 11 is OH.
3. The compound of claim 1 , wherein R 5 is
4. The compound of claim 1 , wherein said compound is:
5. The compound of claim 1 , wherein R 3 is
6. The compound of claim 1 , wherein R 4 is CH 3 .
7. The compound of claim 1 , wherein R 5 is
8. The compound of claim 1 , wherein R 5 is
9. The compound of claim 5 , wherein R 5 is
10. The compound of claim 5 , wherein R 5 is
11. The compound of claim 5 , wherein R 4 is CH 3 , and R 5 is
12. The compound of claim 5 , wherein R 4 is CH 3 , and R 5 is
13. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 1 or a pharmaceutically acceptable salt thereof.
14. A compound described by the following formula:
including both R and S enantiomeric forms and racemic mixtures;
wherein R 4 is
wherein R′ is hydrogen, halogen, CH 3 , or a linear or branched saturated or unsaturated aliphatic chain having at least 2 carbons; and
wherein R 5 is CH 3 or a linear or branched, saturated or unsaturated aliphatic chain having at least 2 carbons.
15. The compound of claim 14 , wherein R 5 is CH 3 .
16. The compound of claim 14 , wherein said compound is:
17. The compound of claim 15 , wherein R 3 is
18. The compound of claim 17 , wherein R 4 is
19. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and compound of claim 14 or a pharmaceutically acceptable salt thereof.