Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same

The present invention relates to novel coordination complexes, methods for synthesizing and identifying coordination complexes, using combinatorial techniques, and assaying their activity. In certain embodiments, the invention relates to a library comprising a plurality of platinum-containing coordination complexes represented by the general formula {PtL n A (4-n) }, wherein, independently for each occurrence, each L is a non-labile ligand under standard conditions, each n is equal to 1, 2 or 3; each A is a labile ligand under standard conditions; and each Pt is Pt(II) or Pt(IV); provided that when Pt is Pt(IV), two additional ligands in the trans axial positions of the general formula depicted are present; and at least one of the plurality of platinum-containing coordination complexes is represented by the formula wherein, independently for each occurrence: X represents halogen or other labile ligand under standard conditions; W represents S, N, or P; Y represents —OR7, —SR7, a halogen or —N(R9)R10; R9 and R10, each independently, represent —H, alkyl, alkenyl, —(CH 2 ) n —R7, or R9 and R10, taken together with the N atom to which they are attached complete a heterocycle having from 4 to about 8 atoms in the ring structure, all optionally substituted; L represents a non-labile ligand under standard conditions; R7 represents —H, alkyl, aryl, cycloalkyl, cycloalkenyl, heterocycle or polycycle; the ligand V comprises W, Y, and a heterocycle having from 4 to about 8 atoms in the ring structure, optionally aromatic and optionally substituted; and the symbol represents a single or a double bond.