IP Library Granted Patent US 7,687,478
Granted Patent B2
US 7,687,478 · App. 10/562,059 · Granted Mar 30, 2010

Disialoundecasaccharide chain asparagine/fatty acid amide and medical drug containing the same

Assignee: Otsuka Chemical Co., Ltd.
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Quick Facts
Patent No.
US 7,687,478
App. No.
10/562,059
Granted
Mar 30, 2010
Kind
B2
Abstract

An asparagine-linked disialoundecaoligosaccharide-fatty acid amide, a drug containing the same, and a drug containing an asparagine-linked disialoundecaoligosaccharide.

Claims (24)

1. An asparagine-linked disialoundecaoligosaccharide-fatty acid amide which does not have an amino acid other than the asparagine, wherein the disialoundecaoligosaccharide has the formula:

and wherein the fatty acid is one having 8 to 24 carbon atoms.

2. An asparagine-linked disialoundecaoligosaccharide-fatty acid amide according to claim 1 wherein the fatty acid is one having 10 to 22 carbon atoms.

3. An asparagine-linked disialoundecaoligosaccharide-fatty acid amide according to claim 2 wherein the fatty acid is at least one selected from the group consisting of capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachic acid, behenic acid and oleic acid.

4. A composition comprising asparagine-linked disialoundecaoligosaccharide-fatty acid amide of claim 1 and a pharmaceutical additive.

5. A composition according to claim 4 wherein the pharmaceutical additive is at least one selected from the group consisting of lactose, glycerin, glucose, sucrose and mannitol.

6. A drug containing the asparagine-linked disialoundecaoligosaccharide-fatty acid amide of claim 1 .

7. A drug comprising at least one selected from asparagine-linked disialoundecaoligosaccharide-fatty acid amide of claim 1 and asparagine-linked disialoundecaoligosaccharide having formula 3:

and a pharmaceutical additive.

8. A composition comprising asparagine-linked disialoundecaoligosaccharide-fatty acid amide of claim 2 , and a pharmaceutical additive.

9. A composition comprising asparagine-linked disialoundecaoligosaccharide-fatty acid amide of claim 3 , and a pharmaceutical additive.

10. A composition according to claim 8 wherein the pharmaceutical additive is at least one selected from the group consisting of lactose, glycerin, glucose, sucrose and mannitol.

11. A composition according to claim 9 wherein the pharmaceutical additive is at least one selected from the group consisting of lactose, glycerin, glucose, sucrose and mannitol.

12. A method of treating influenza comprising administering a therapeutically effectively amount of an asparagine-linked disialoundecaoligosaccharide-fatty acid amide of claim 1 to a subject in need of such treatment.

13. A method of treating influenza comprising administering a therapeutically effective amount of an asparagine-linked disialoundecaoligosaccharide-fatty acid amide of claim 2 to a subject in need of such treatment.

14. A method of treating influenza comprising administering a therapeutically effective amount of an asparagine-linked disialoundecaoligosaccharide-fatty acid amide of claim 3 to a subject in need of such treatment.

15. A method of treating influenza comprising administering a therapeutically effective amount of a composition of claim 4 to a subject in need of such treatment.

16. A method of treating influenza comprising administering a therapeutically effective amount of a composition of claim 5 to a subject in need of such treatment.

17. A method of treating influenza comprising administering a therapeutically effective amount of a composition of claim 8 to a subject in need of such treatment.

18. A method of treating influenza comprising administering a therapeutically effective amount of a composition of claim 9 to a subject in need of such treatment.

19. A method of treating influenza comprising administering a therapeutically effective amount of a composition of claim 10 to a subject in need of such treatment.

20. A method of treating influenza comprising administering a therapeutically effective amount of a composition of claim 11 to a subject in need of such treatment.

21. A method of treating influenza comprising administering a therapeutically effective amount of a drug of claim 6 to a subject in need of such treatment.

22. A method of treating influenza comprising administering a therapeutically effective amount of a drug of claim 7 to a subject in need of such treatment.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 1, 2013
From: OTSUKA CHEMICAL CO., LTD.
To: GLYTECH, INC.
Reel/Frame 030723/0810 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 29, 2009
From: OTSUKA CHEMICAL CO., LTD.
To: OTSUKA CHEMICAL HOLDINGS CO., LTD.
Reel/Frame 023295/0134 →
CHANGE OF NAME Recorded Sep 29, 2009
From: OTSUKA CHEMICAL HOLDINGS CO., LTD.
To: OTSUKA CHEMICAL CO., LTD.
Reel/Frame 023295/0191 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 22, 2005
From: MAEDA, HIROAKI; FUKAE, KAZUHIRO
To: OTSUKA CHEMICAL CO., LTD.
Reel/Frame 017408/0527 →
Priority Claims (1)
JP 2003-187931 · Jun 30, 2003 · national
Continuity (1)
Related Publication 20070105813A1 · May 10, 2007