IP Library › Granted Patent US 7,704,756
Granted Patent B2
US 7,704,756 · App. 11/343,886 · Granted Apr 27, 2010

Fluorogenic dyes

Assignee: Novartis Vaccines and Diagnostics, Inc.
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Quick Facts
Patent No.
US 7,704,756
App. No.
11/343,886
Granted
Apr 27, 2010
Kind
B2
Abstract

Fluorogenic or chromogenic dyes are useful as reporter molecules for detecting cell entry by a specific molecule.

Claims (6)

1. A library of compounds that is to be screened for their ability to be internalized by a desired cell, the library comprising a plurality of different compounds, wherein the different compounds in such library are covalently attached to a fluorogenic reporter molecule that becomes fluorescent after it is internalized by a cell, and wherein the reporter molecule is selected from the group consisting of:

2. The library of claim 1 , wherein the reporter molecule is:

3. The library of claim 1 , wherein the reporter molecule is:

4. A fluorogenic compound having a structure selected from the group consisting of:

5. The fluorogenic compound of claim 4 , wherein the structure is:

6. The fluorogenic compound of claim 4 , wherein the structure is:

Assignments (1)
CHANGE OF NAME Recorded Feb 22, 2010
From: CHIRON CORPORATION
To: NOVARTIS VACCINES AND DIAGNOSTICS, INC.
Reel/Frame 023970/0466 →
Continuity (2)
Division 1034925600 · Jan 21, 2003
Related Publication 20060128033A1 · Jun 15, 2006