Sustained-release formulation and uses thereof
The present invention provides sustained-release formulations useful and methods for using the same.
1. A delayed release composition comprising compound 2:
2. The composition according to claim 1 , wherein the delayed release component comprises hypromellose, microcrystalline cellulose, and a lubricant.
3. The composition according to claim 1 , wherein said composition is compressed into a tablet.
4. A multiparticulate formulation comprising a pellet core which comprises compound 2:
a non-functional seal coating and a functional seal coating.
5. The composition according to claim 1 , comprising Form I of compound 2 and one or more additional solid forms of compound 2.
6. The composition according to claim 5 , comprising Form I of compound 2 and one or more of Form II, a hydrate of compound 2, a solvate of compound 2, or amorphous compound 2.
7. The composition according to claim 5 , wherein Form I of compound 2 comprises one or more peaks in its X-ray diffraction pattern chosen from those having about the following values: 17.5, 22.5, 19.9, 3.9, and 12.2 degrees 2-theta.
8. The composition according to claim 6 , wherein said hydrate of compound 2 is chosen from Hydrate I or Hydrate II.
9. The composition according to claim 6 , wherein said solvate of compound 2 is chosen from Methanolate, Ethanolate I, Ethanolate II, Isopropanolate I, Isopropanolate II, and Acetonate.