Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
1. A method of treating cachexia comprising administering to an animal having cachexia a therapeutically effective amount of triacetyluridine.
2. A method as in claim 1 further comprising administering an inhibitor of uridine phosphorylase selected from the group consisting of 5-benzyl barbiturate, 5-benzyloxybenzyl barbiturate, 5-benzyloxybenzyl-1-[(1-hydroxy-2-ethoxy)methyl] barbiturate, 5-benzyloxybenzylacetyl-1-[(1-hydroxy-2-ethoxy)methyl] barbiturate, 5-methoxybenzylacetylacyclobarbiturate, 2,2′-anhydro-5-ethyluridine, benzylacyclouridine, benzyloxybenzylacyclouridine, aminomethyl-benzylacyclouridine, aminomethylbenzyloxybenzylacyclouridine, hydroxymethylbenzylacyclouridine and hydroxymethyl-benzyloxybenzylacyclouridine.