IP Library Granted Patent US 7,725,192
Granted Patent B2
US 7,725,192 · App. 11/545,808 · Granted May 25, 2010

Methods of increasing learning rate

Assignee: The General Hospital Corporation
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Quick Facts
Patent No.
US 7,725,192
App. No.
11/545,808
Granted
May 25, 2010
Kind
B2
Abstract

The invention relates, in part, to methods of administering electrical or magnetic brain stimulation to increase learning rate.

Claims (19)

1. A method for increasing the rate of learning in a subject, the method comprising,

electrically stimulating the striatum in the brain of the subject during an interval of learning in the subject, wherein the interval of learning comprises a reinforcement interval that is a feedback period of learning.

2. The method of claim 1 , wherein the learning comprises formation of a visual-motor association.

3. The method of claim 1 , wherein stimulating the striatum is stimulating the caudate.

4. The method of claim 1 , wherein stimulating the striatum is stimulating the anterior caudate.

5. The method of claim 1 , wherein the stimulation of the striatum comprises deep brain stimulation.

6. The method of claim 5 , wherein the deep brain stimulation comprises high frequency microstimulation.

7. The method of claim 6 , wherein the high frequency microstimulation is at a pulse frequency of about 200 Hz.

8. The method of claim 6 , wherein the high frequency micro stimulation is at a phase length of about 0.2 ms.

9. The method of claim 6 , wherein the high frequency microstimulation is at an interphase interval of about 0.2 ms.

10. The method of claim 6 , wherein the high frequency microstimulation is at an amperage of about 200 μA.

11. The method of claim 6 , wherein the high frequency microstimulation comprises a stimulus train of about 1000 ms.

12. The method of claim 1 , wherein the stimulation of the striatum comprises epidural electrical stimulation.

13. The method of claim 1 , wherein the subject has, has had, or is suspected of having a neurological disease or disorder.

14. The method of claim 13 , wherein the neurological disease or disorder is associated with a deficit in learning.

15. The method of claim 13 , wherein the neurological disease or disorder is a associated with a deficit in the formation of visual-motor associations.

16. The method of claim 13 , wherein the neurological disease or disorder is an associative learning disorder, a brain injury, a neurodegenerative disorder, stroke, epilepsy, autism, or Parkinson's disease.

17. The method of claim 1 , wherein the subject is a primate.

18. The method of claim 1 , wherein the subject is a human.

Assignments (4)
CONFIRMATORY LICENSE Recorded Feb 4, 2019
From: THE GENERAL HOSPITAL CORPORATION
To: NIH - DEITR
Reel/Frame 048226/0400 →
CONFIRMATORY LICENSE Recorded Jul 30, 2010
From: MASSACHUSETTS GENERAL HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024764/0905 →
EXECUTIVE ORDER 9424, CONFIRMATORY LICENSE Recorded Feb 26, 2009
From: GENERAL HOSPITAL CORPORATION DBA MASS
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022315/0187 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 21, 2007
From: ESKANDAR, EMAD; WILLIAMS, ZIV
To: THE GENERAL HOSPITAL CORPORATION
Reel/Frame 019318/0468 →
Continuity (2)
Provisional Application 6072577100 · Oct 12, 2005
Related Publication 20070225774A1 · Sep 27, 2007