Method of treating pancreatitis
The present invention provides a method of treating pancreatitis comprising administering to a human in need thereof an effective amount of hemin. The administration of hemin is preferably parenteral. In another aspect, the present invention provides a method of pancreatitis prophylaxis comprising administering to a human in need thereof an effective amount of hemin. In a still further aspect, the present invention contemplates a method of inducing an HO gene comprising administering to a human in need thereof an HO-inducing effective amount of hemin. Preferably, the HO gene is the HO-1 gene. In a still further aspect, the present invention contemplates a method of inducing an HO gene in leukocytes for recruitment to the pancreas to treat pancreatitis comprising administering to a human in need thereof an HO-inducing effective amount of hemin. In another embodiment, the present invention contemplates a method of inducing an HO gene in leukocytes for recruitment to the pancreas for prophylaxis of pancreatitis comprising administering to a human in need thereof an HO-inducing effective amount of hemin. In a yet further aspect, the present invention provides a method of ex vivo treatment of pancreatitis comprising providing peripheral blood leukocytes, followed by contact with hemin to form induced peripheral blood leukocytes then infusing the induced peripheral blood leukocytes into a human in need thereof.
1. A method of treating pancreatitis comprising administering to a human in need thereof an effective amount of hemin.
2. A method of pancreatitis prophylaxis comprising administering to a human in need thereof an effective amount of hemin.
3. The method of claims 1 or 2 wherein said hemin is administered via a parenteral route.
4. The method of claim 3 wherein said pareneteral route is intravenous.
5. The method of claim 3 wherein said parenteral route is intraperitoneal.