Pyridazine compound and use thereof
View Patent ↗A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating compound (1) are provided.
1. A compound having the formula (1)
and the salts thereof.
2. The compound of claim 1 as the free base.
3. The compound of claim 1 as a suspension.
4. The suspension of claim 1 in an aqueous medium.
5. The compound of claim 1 as a solution.
6. The compound of claim 5 in solution with a C4-C22 fatty acid.
7. The solution of claim 6 wherein the fatty acid is oleic acid or lauric acid.
8. A composition comprising the compound of claim 1 and a pharmaceutically acceptable excipient.
9. The composition of claim 8 wherein the excipient is a C4-C22 fatty acid.
10. The composition of claim 9 which is an aqueous solution and wherein the fatty acid is oleic acid.
11. A method for therapy of an HCV infection comprising administering to a subject in need thereof an HCV therapeutic dose of the compound of claim 1 .
12. The method of claim 11 wherein the subject is a human.
13. The method of claim 12 further comprising administering to the subject a therapeutically effective dose of another agent for the treatment of an HCV infection.
14. The method of claim 12 wherein the agent is an interferon.
15. The method of claim 12 wherein the therapeutically effective dose is about from 0.5-5.0 mg/kg BID.
16. The method of claim 15 wherein the dose is about from 0.7-2.2 mg/kg BID.