Multi-phasic nanoparticles
View Patent ↗A method of forming multi-phasic nano-objects involves the jetting of two or more different liquids in side-by-side capillaries thereby generating a composite liquid stream. The composite then exposed to a force field which causes the composite liquid stream to at least partially solidify into a nano-object. The method forms a nano-object having a number of morphologies such as rods, spheres, and fibers.
1. A nano-object having at least one spatial dimension of about 5 nm to about 5000 nm comprising multiple chemically distinct exposed surface regions, wherein at least two of the multiple chemically distinct exposed surface regions independently comprise a polymeric material.
2. The nano-object of claim 1 wherein the nano-object is a biphasic nano-object.
3. The nano-object of claim 1 wherein the nano-object has a morphology selected from the group consisting of spheres, rods, fibers, and combinations thereof.
4. The nano-object of claim 1 wherein one or more of the multiple chemically distinct exposed surface regions comprises an additive.
5. The nano-object of claim 4 wherein the additive is selected from the group consisting of inorganic nanocrystals, quantum dots, biomolecules, colorants, crosslinkers, pharmaceutical compounds, molecular probes, and molecules that enable drug delivery.
6. The nano-object of claim 4 wherein the additive is a colorant.
7. The nano-object of claim 6 , wherein the nano-object is a multiphase colorant.
8. The nano-object of claim 1 , wherein at least two of the multiple chemically distinct exposed surface regions have different colors.
9. The nano-object of claim 1 , wherein the nano-object is spherical.
10. The nano-object of claim 1 , wherein the nano-object is non-spherical.
11. The nano-object of claim 1 , wherein the nano-object comprises at least two phases.
12. The nano-object of claim 11 , wherein at least two of the phases form a side-by-side morphology.
13. The nano-object of claim 11 , wherein one or more of the phases includes one or more reactive components that react with a structural component thereby rendering a resulting surface of the nano-object chemically modified as compared to the surface when the one or more reactive components are not present.
14. The nano-object of claim 11 , wherein at least one of the phases contains a drug.
15. The nano-object of claim 1 , wherein the polymeric material is formed from a curable polymer precursor, a polymer solution, and/or a polymer melt.
16. The nano-object of claim 1 , wherein the polymeric material comprises a polymer selected from the group consisting of: polyethylene glycol, polycaprolactone, polyglycolic acid, and combinations thereof.
17. The nano-object of claim 1 , wherein the polymeric material has been cured thermally or by exposure to actinic radiation.
18. The nano-object of claim 1 , wherein the nano-object has a spatial dimension between about 20 nm and about 2000 nm.
19. The nano-object of claim 1 , wherein the nano-object has a spatial dimension between about 50 nm and 500 nm.
20. The nano-object of claim 1 , wherein at least one of the multiple chemically distinct surface regions contains a receptor.
21. The nano-object of claim 20 , wherein at least one distinct surface of each particle contains a common receptor.
22. A nano-object having at least one spatial dimension of about 5 nm to about 5000 nm comprising at least two phases each independently comprising a polymeric material wherein the nano-object has at least two distinct exposed surface regions, wherein the nano-object has a morphology selected from the group consisting of spheres, rods, fibers and combinations thereof.
23. The nano-object of claim 22 , wherein the nano-object is a biphasic nano-object.
24. The nano-object of claim 22 , wherein the nano-object further comprises an additive.
25. The nano-object of claim 24 , wherein the additive is selected from the group consisting of inorganic nanocrystals, quantum dots, biomolecules, colorants, crosslinkers, pharmaceutical compounds, molecular probes, and molecules that enable drug delivery.
26. The nano-object of claim 24 , wherein the additive is a colorant.
27. The nano-object of claim 22 , wherein at least two of the phases have different colors.
28. The nano-object of claim 22 , wherein the nano-object has a spatial dimension between about 20 nm and about 2000 nm.
29. The nano-object of claim 22 , wherein the nano-object has a spatial dimension between about 50 nm and 500 nm.
30. The nano-object of claim 22 , wherein the nano-object is non-spherical.
31. The nano-object of claim 22 , wherein the nano-object is spherical.
32. The nano-object of claim 22 , wherein at least one of the multiple phases contains a drug.
33. The nano-object of claim 22 , wherein at least one of the phases contains a receptor.
34. A nano-object having at least one spatial dimension of about 5 nm to about 5000 nm comprising at least two chemically distinct phases that form multiple chemically distinct exposed surfaces to define sides of the nano-object, wherein each of the at least two chemically distinct phases independently comprises a polymeric material.