Implantable device for recording intracranial pressures
View Patent ↗To assure, in the case of an implantable device for determining intracranial pressures, the biocompatibility of the implant in the long term, wherein a pressure measuring device is used, which is operatively connected to a sensor for a telemetric measured value transfer, it is proposed that the pressure measuring device is a microchip, that the microchip is located in a rigid housing, and that the pressure transfer from the outside inwards occurs through a very thin biocompatible membrane, the pressure-dependent movement of which acts on the pressure measuring device via a transfer medium.
1. Implantable device for determining intracranial pressures, comprising:
a rigid housing defining a housing interior;
a thin biocompatible membrane closing off at least a portion of the housing interior; and
a pressure measuring device arranged in the housing interior, the pressure measuring device being a microchip which comprises a pressure sensor for determining a value of a pressure transfer occurring through the membrane from an outside of the membrane inwards towards the housing interior, wherein:
the value of the pressure transfer is telemetrically communicated via the pressure measuring device;
a pressure-dependent movement of the membrane acts on the pressure measuring device via a transfer medium,
the transfer medium comprises one of air or a special gas,
the housing interior is filled with a gas-displacing filler material except for a provided volume of the transfer medium,
the rigid housing has a closed fluid chamber which adjoins the membrane on the outside of the membrane and is connected to a supply conduit for fluid,
the rigid housing has the shape of a shallow can with an upper measurement chamber receiving the microchip and the transfer medium and a lower region forming the fluid chamber,
the membrane divides the housing interior into the measurement chamber and the fluid chamber,
the supply conduit for fluid runs substantially perpendicular in relation to a lower boundary wall of the fluid chamber.
2. Device according to claim 1 , wherein the transfer medium comprises a gas from the group of noble gases.
3. Device according to claim 1 , wherein:
a gas is used as transfer medium, and
a gas volume of the gas is less than a cubic millimetre.
4. Device according to claim 1 , wherein the filler material is one of plastic, ceramic or a metal material.
5. Device according to claim 1 , wherein:
the filler material forms a minimum-volume pressure chamber including a supply duct on pressure-sensitive faces of the microchip,
the filler material forms a housing cavity as pressure chamber below the membrane, and
the two pressure chambers are connected by a small-volume conduit.
6. Device according to claim 1 , wherein the housing is made of ceramic.
7. Device according to claim 1 , wherein the housing is made of a biocompatible plastic.
8. Device according to claim 7 , wherein the housing is made of one of polyether ether ketone or polyether ketone ketone.
9. Device according to claim 1 , wherein the housing is made of metal.
10. Device according to claim 9 , wherein the housing is made of one of titanium or a titanium alloy.
11. Device according to claim 1 , wherein the membrane is made of metal.
12. Device according to claim 11 , wherein the membrane is made of one of titanium or a titanium alloy.
13. Device according to claim 1 , wherein the membrane has a thickness of less than 0.05 millimetres.
14. Device according to claim 1 , wherein the membrane has a flexible surface of about one of 100 mm 2 , 1 mm 2 , and 4 mm 2 .
15. Device according to claim 1 , wherein the membrane is welded to the housing.
16. Device according to claim 15 , wherein the membrane is provided with a sheet metal frame and is welded with the frame to the housing.
17. Device according to claim 1 , wherein the membrane is configured in one piece with the housing.
18. Device according to claim 1 , wherein the membrane has regions of different thickness.
19. Device according to claim 18 , wherein the membrane is thicker in its edge regions than in its central region.
20. Device according to claim 1 , wherein besides the pressure sensor, the microchip comprises at least one further sensor.
21. Device according to claim 20 , wherein the microchip further comprises an analog-to-digital converter, which converts the analog electrical signals of the sensors into digital signals.
22. Device according to claim 1 , the microchip is arranged on a support.
23. Device according to claim 22 , wherein the support is bend-resistant.
24. Device according to claim 22 , wherein the support carries further electronic components.
25. Device according to claim 24 , wherein the support has connection leads for at least one of the microchip and the further electronic components.
26. Device according to claim 22 , wherein the microchip or the support is connected to a power and signal transmission line, which line connects to a data processing device outside a body or to a transmission coil.
27. Device according to claim 26 , wherein the transmission coil is arranged in the rigid housing.
28. Device according to claim 1 , wherein the rigid housing is partially provided with a plastic casing or a plastic covering, which leaves at the least the surface of the membrane free.
29. Device according to claim 1 , wherein the fluid chamber additionally has a drainage pipe for brain fluid.
30. Device according to claim 1 , wherein the supply conduit for fluid enters the fluid chamber approximately centrally.
31. Device according to claim 29 , wherein the drainage pipe for the brain fluid runs parallel to a floor surface of the fluid chamber.
32. Device according to claim 29 , wherein a non-return valve is arranged in the drainage pipe.
33. Device according to claim 29 , wherein the drainage pipe opens into a reservoir.
34. Device according to claim 1 , wherein the supply conduit is connected to an extension tube, which is open at its end remote from the fluid chamber.
35. Device according to claim 1 , wherein:
the supply conduit is connected to an extension tube, which is closed at its end remote from the fluid chamber by means of a flexible membrane, and
the fluid chamber filled with a liquid or a gas is closed off except for the supply conduit.
36. Device according to claim 1 , wherein a wall thickness of the rigid housing lies between 0.3 mm and 0.2 mm.
37. Device according to claim 1 , wherein walls of the rigid housing are protected against deformation by reinforcement structures.
38. Device according to claim 1 , wherein:
the measurement chamber is arranged in an insert, which can be inserted into the housing and closes the housing in the manner of a cover, and
the insert carries the membrane, which separates the measurement chamber from the fluid chamber.
39. Device according to claim 38 , wherein the membrane is a metal foil, which is soldered or welded to the insert receiving the measurement chamber.
40. Device according to claim 39 , wherein:
the insert receiving the measurement chamber has a planar rim, against which the membrane lies flat,
an annular abutment element is arranged opposite the planar rim on the side opposite the insert, and
the membrane is soldered or welded both to the insert and to the abutment element.
41. Device according to claim 39 , wherein, the element is made of metal.
42. Device according to claim 40 , wherein the abutment element is made of metal.
43. Device according to claim 39 , wherein the membrane is made of metal.
44. Device according to claim 43 , wherein the thickness of the membrane lies between 1/100 mm and 5/100 mm.
45. Device according to claim 40 , wherein the abutment element has a height of between 2/10 and 8/10 mm.