Compositions and methods for inhibiting drusen complement components C3a and C5a for the treatment of age-related macular degeneration
Activated C3 (C3a) and its receptor (C3aR) and activated C5 (C5a) and its receptor (C5aR) have been shown to induce vascular endothelial growth factor (VEGF) expression in vitro and in vivo. Compositions and methods for inhibiting C3a, C3aR, C5a and C5aR for the treatment and/or prevention of neovascular disease are provided. Also provided are Novel therapeutic targets and diagnostic markers for choroidal neovascularization.
1. A pharmaceutical composition for treating and/or preventing choroidal neovascularization (CNV) comprising, a therapeutically effective amount of an antibody that binds selectively to the receptor of C3a (C3aR), and prevents choroidal neovascularization and an ophthalmically acceptable pharmaceutical carrier, wherein the antibody comprises a pharmaceutical agent operatively attached thereto.
2. The composition according to claim 1 wherein the pharmaceutical agent is an anti-inflammatory agent.
3. The composition of claim 1 wherein the pharmaceutical agent is a radioisotope.
4. The composition of claim 3 wherein the radioisotope is 211 Astatine or 131 Iodine.
5. The composition of claim 1 wherein said composition is formulated for intravitreous injection.